Correlation between hospital-level antibiotic consumption and incident health care facility-onset Clostridium difficile infection

Page E. Crew, Nathaniel J. Rhodes, J. Nicholas O'Donnell, Cristina Miglis, Elise M. Gilbert, Teresa R. Zembower, Chao Qi, Christina Silkaitis, Sarah H. Sutton, Marc H. Scheetz*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: The purpose of this single-center, ecologic study is to characterize the relationship between facility-wide (FacWide) antibiotic consumption and incident health care facility-onset Clostridium difficile infection (HO-CDI). Methods: FacWide antibiotic consumption and incident HO-CDI were tallied on a monthly basis and standardized, from January 2013 through April 2015. Spearman rank-order correlation coefficients were calculated using matched-months analysis and a 1-month delay. Regression analyses were performed, with P <.05 considered statistically significant. Results: FacWide analysis identified a matched-months correlation between ceftriaxone and HO-CDI (ρ = 0.44, P =.018). A unit of stem cell transplant recipients did not have significant correlation between carbapenems and HO-CDI in matched months (ρ = 0.37, P =.098), but a significant correlation was observed when a 1-month lag was applied (ρ = 0.54, P =.014). Discussion: Three statistically significant lag associations were observed between FacWide/unit-level antibiotic consumption and HO-CDI, and 1 statistically significant nonlagged association was observed FacWide. Antibiotic consumption may convey extended ward-level risk for incident CDI. Conclusions: Consumption of antibiotic agents may have immediate and prolonged influence on incident CDI. Additional studies are needed to investigate the immediate and delayed associations between antibiotic consumption and C difficile colonization, infection, and transmission at the hospital level.

Original languageEnglish (US)
Pages (from-to)270-275
Number of pages6
JournalAmerican Journal of Infection Control
Volume46
Issue number3
DOIs
StatePublished - Mar 2018

Keywords

  • Antibiotic use
  • Antimicrobial stewardship
  • Healthcare-associated infections
  • Statistical model

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Correlation between hospital-level antibiotic consumption and incident health care facility-onset Clostridium difficile infection'. Together they form a unique fingerprint.

  • Cite this