Correlation between novel 3D high-resolution manometry esophagogastric junction metrics and pH-metry in reflux disease patients

Y. Xiao, Z. Lin, Y. Li, J. E. Pandolfino, M. Chen*, P. J. Kahrilas

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background and aims: We recently developed 2 novel 3D high-resolution manometry (HRM) metrics of esophagogastric junction (EGJ) contractility to differentiate the lower esophageal sphincter (LES) and crural diaphragm (CD) elements of EGJ pressure. This study aimed to compare these metrics to the EGJ-contractile integral (EGJ-CI) and to analyze their correlation with esophageal acid exposure time (AET) on pH-metry. Methods: Thirty-one gastro-oesophageal reflux disease (GERD) patients and 20 control subjects underwent 24-hour pH-metry and HRM using a 3D-HRM catheter. EGJ metrics were calculated during 3 consecutive respiratory cycles at rest. The EGJ-CI was calculated using the DCI tool in the ManoView software. 3D LES pressure (3D-LESP) and 3D-DHA, a metric quantifying the CD component of the 3D-HRM pressure topography, were calculated using a MATLAB program. Pearson correlation was used to calculate correlations with AET. Key Results: 3D-LESP, 3D-DHA, and EGJ-CI were all significantly lower in GERD patients than in control subjects (P <.05) and all were significantly correlated with AET (R = −.48, −.42, −.52, respectively, all P <.01). The 3D-DHA and EGJ-CI also strongly correlated with each other (R =.84, P <.001). Conclusions & Inferences: Both 3D-EGJ metrics were correlated with AET emphasizing the importance of both LES and CD function as a determinant of EGJ competence. 3D-DHA also strongly correlated with the EGJ-CI suggesting that EGJ-CI is strongly driven by the asymmetrical CD pressure component.

Original languageEnglish (US)
Article numbere13344
JournalNeurogastroenterology and Motility
Volume30
Issue number9
DOIs
StatePublished - Sep 2018

Keywords

  • crural diaphragm
  • diaphragmatic hiatus
  • esophagogastric junction
  • gastro-oesophageal reflux disease
  • high-resolution manometry

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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