TY - JOUR
T1 - Correlation between serum prostate-specific antigen and cancer volume in prostate glands of different sizes
AU - Carvalhal, Gustavo F.
AU - Daudi, Saima N.
AU - Kan, Donghui
AU - Mondo, Dana
AU - Roehl, Kimberly A.
AU - Loeb, Stacy
AU - Catalona, William J.
N1 - Funding Information:
Supported in part by the Urological Research Foundation , Beckman Coulter, Inc. , Prostate SPORE grant ( P50 CA90386-05S2 ), and Robert H. Lurie Comprehensive Cancer Center grant ( P30 CA60553 ).
PY - 2010/11
Y1 - 2010/11
N2 - Objectives: To further evaluate the relationship of prostate-specific antigen (PSA) with prostate size and tumor volume in a contemporary surgical series. Although early studies showed a strong correlation between PSA and tumor volume, it has been suggested that PSA is no longer a valid marker for prostate cancer and only correlates with prostate size. Methods: From 2003 to 2009, 1234 men with data on prostate weight and total tumor volume underwent radical prostatectomy by a single surgeon. Prostate size was classified into tertiles: small (≤41.2 g), medium (41.3-54.5 g), and large (≥54.6 g). Pearson correlation coefficients were used to examine the relationship of PSA with prostate size and tumor volume across different prostate sizes. Results: Median preoperative PSA was 4.9 ng/mL (standard deviation ± 4.6), mean prostate size was 51.7 g, and mean tumor volume was 5.6 cm3. PSA had a significant correlation with prostate size only at a prostate weight ≥54.6 g (P = .02). Regardless of prostate size, PSA had a more robust significant correlation with tumor volume than with prostate size (all P <.0001). Conclusions: PSA was significantly correlated with prostate size only in the largest prostate glands, but was significantly associated with tumor volume in small, medium, or large prostates. Thus, PSA continues to be a better marker for tumor volume than for prostate size.
AB - Objectives: To further evaluate the relationship of prostate-specific antigen (PSA) with prostate size and tumor volume in a contemporary surgical series. Although early studies showed a strong correlation between PSA and tumor volume, it has been suggested that PSA is no longer a valid marker for prostate cancer and only correlates with prostate size. Methods: From 2003 to 2009, 1234 men with data on prostate weight and total tumor volume underwent radical prostatectomy by a single surgeon. Prostate size was classified into tertiles: small (≤41.2 g), medium (41.3-54.5 g), and large (≥54.6 g). Pearson correlation coefficients were used to examine the relationship of PSA with prostate size and tumor volume across different prostate sizes. Results: Median preoperative PSA was 4.9 ng/mL (standard deviation ± 4.6), mean prostate size was 51.7 g, and mean tumor volume was 5.6 cm3. PSA had a significant correlation with prostate size only at a prostate weight ≥54.6 g (P = .02). Regardless of prostate size, PSA had a more robust significant correlation with tumor volume than with prostate size (all P <.0001). Conclusions: PSA was significantly correlated with prostate size only in the largest prostate glands, but was significantly associated with tumor volume in small, medium, or large prostates. Thus, PSA continues to be a better marker for tumor volume than for prostate size.
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U2 - 10.1016/j.urology.2009.11.056
DO - 10.1016/j.urology.2009.11.056
M3 - Article
C2 - 20846711
AN - SCOPUS:78149357044
SN - 0090-4295
VL - 76
SP - 1072
EP - 1076
JO - Urology
JF - Urology
IS - 5
ER -
