Correlation of HIV-specific immunity, viral control, and diversification following planned multiple exposures to autologous HIV in a pediatric population

William Borkowsky*, Elizabeth J. McFarland, Ram Yogev, Yonghua Li, Paul Harding

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Repeated controlled exposure to autologous virus was previously shown to result in increased CD8 T lymphocyte response to HIV antigens and accompanying reduction in viremia. We attempted to see if this immunity contributed to virologic control by correlating the immune response with quasispecies envelope diversification, an indicator of immune selection. The greatest diversification was seen in those with the greatest reduction in viremia but was unrelated to the frequency of Env-specific gamma interferon-producing cells. There was a trend toward correlation between the response to multiple HIV antigens and diversification.

Original languageEnglish (US)
Pages (from-to)1628-1631
Number of pages4
JournalClinical and Vaccine Immunology
Volume18
Issue number10
DOIs
StatePublished - Oct 1 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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