TY - JOUR
T1 - Correlation of HIV-specific immunity, viral control, and diversification following planned multiple exposures to autologous HIV in a pediatric population
AU - Borkowsky, William
AU - McFarland, Elizabeth J.
AU - Yogev, Ram
AU - Li, Yonghua
AU - Harding, Paul
PY - 2011/10
Y1 - 2011/10
N2 - Repeated controlled exposure to autologous virus was previously shown to result in increased CD8 T lymphocyte response to HIV antigens and accompanying reduction in viremia. We attempted to see if this immunity contributed to virologic control by correlating the immune response with quasispecies envelope diversification, an indicator of immune selection. The greatest diversification was seen in those with the greatest reduction in viremia but was unrelated to the frequency of Env-specific gamma interferon-producing cells. There was a trend toward correlation between the response to multiple HIV antigens and diversification.
AB - Repeated controlled exposure to autologous virus was previously shown to result in increased CD8 T lymphocyte response to HIV antigens and accompanying reduction in viremia. We attempted to see if this immunity contributed to virologic control by correlating the immune response with quasispecies envelope diversification, an indicator of immune selection. The greatest diversification was seen in those with the greatest reduction in viremia but was unrelated to the frequency of Env-specific gamma interferon-producing cells. There was a trend toward correlation between the response to multiple HIV antigens and diversification.
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U2 - 10.1128/CVI.05176-11
DO - 10.1128/CVI.05176-11
M3 - Article
C2 - 21813662
AN - SCOPUS:80053450346
SN - 1556-6811
VL - 18
SP - 1628
EP - 1631
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
IS - 10
ER -
