Correlation of plasma and CSF prolactin with CSF GABA during neuroleptic treatment

Malcolm B. Bowers*, Herbert Y. Meltzer, George R. Heninger

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We measured serum and CSF prolactin and CSF 5HIAA, HVA and GABA at two time points separated by an average period of 21 days during the beginning of neuroleptic treatment in 26 psychotic patients. Prolactin levels were higher in females at both time points, and there was little evidence of tolerance during the measurement period. The prolactin values showed considerable intercorrelation. CSF GABA tended to be negatively correlated with prolactin values, particularly in male subjects. There were few significant correlations between the prolactin measures and CSF metabolites or clinical ratings.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalLife Sciences
Volume31
Issue number1
DOIs
StatePublished - Jul 5 1982

Fingerprint

Prolactin
gamma-Aminobutyric Acid
Antipsychotic Agents
Plasmas
Therapeutics
Metabolites
Serum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Bowers, Malcolm B. ; Meltzer, Herbert Y. ; Heninger, George R. / Correlation of plasma and CSF prolactin with CSF GABA during neuroleptic treatment. In: Life Sciences. 1982 ; Vol. 31, No. 1. pp. 59-65.
@article{8909613d201949d2b71f9194e983dab9,
title = "Correlation of plasma and CSF prolactin with CSF GABA during neuroleptic treatment",
abstract = "We measured serum and CSF prolactin and CSF 5HIAA, HVA and GABA at two time points separated by an average period of 21 days during the beginning of neuroleptic treatment in 26 psychotic patients. Prolactin levels were higher in females at both time points, and there was little evidence of tolerance during the measurement period. The prolactin values showed considerable intercorrelation. CSF GABA tended to be negatively correlated with prolactin values, particularly in male subjects. There were few significant correlations between the prolactin measures and CSF metabolites or clinical ratings.",
author = "Bowers, {Malcolm B.} and Meltzer, {Herbert Y.} and Heninger, {George R.}",
year = "1982",
month = "7",
day = "5",
doi = "10.1016/0024-3205(82)90401-5",
language = "English (US)",
volume = "31",
pages = "59--65",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "1",

}

Correlation of plasma and CSF prolactin with CSF GABA during neuroleptic treatment. / Bowers, Malcolm B.; Meltzer, Herbert Y.; Heninger, George R.

In: Life Sciences, Vol. 31, No. 1, 05.07.1982, p. 59-65.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation of plasma and CSF prolactin with CSF GABA during neuroleptic treatment

AU - Bowers, Malcolm B.

AU - Meltzer, Herbert Y.

AU - Heninger, George R.

PY - 1982/7/5

Y1 - 1982/7/5

N2 - We measured serum and CSF prolactin and CSF 5HIAA, HVA and GABA at two time points separated by an average period of 21 days during the beginning of neuroleptic treatment in 26 psychotic patients. Prolactin levels were higher in females at both time points, and there was little evidence of tolerance during the measurement period. The prolactin values showed considerable intercorrelation. CSF GABA tended to be negatively correlated with prolactin values, particularly in male subjects. There were few significant correlations between the prolactin measures and CSF metabolites or clinical ratings.

AB - We measured serum and CSF prolactin and CSF 5HIAA, HVA and GABA at two time points separated by an average period of 21 days during the beginning of neuroleptic treatment in 26 psychotic patients. Prolactin levels were higher in females at both time points, and there was little evidence of tolerance during the measurement period. The prolactin values showed considerable intercorrelation. CSF GABA tended to be negatively correlated with prolactin values, particularly in male subjects. There were few significant correlations between the prolactin measures and CSF metabolites or clinical ratings.

UR - http://www.scopus.com/inward/record.url?scp=0020328066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020328066&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(82)90401-5

DO - 10.1016/0024-3205(82)90401-5

M3 - Article

C2 - 6125865

AN - SCOPUS:0020328066

VL - 31

SP - 59

EP - 65

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 1

ER -