Correlation of plasma and CSF prolactin with CSF GABA during neuroleptic treatment

Malcolm B. Bowers*, Herbert Y. Meltzer, George R. Heninger

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We measured serum and CSF prolactin and CSF 5HIAA, HVA and GABA at two time points separated by an average period of 21 days during the beginning of neuroleptic treatment in 26 psychotic patients. Prolactin levels were higher in females at both time points, and there was little evidence of tolerance during the measurement period. The prolactin values showed considerable intercorrelation. CSF GABA tended to be negatively correlated with prolactin values, particularly in male subjects. There were few significant correlations between the prolactin measures and CSF metabolites or clinical ratings.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalLife Sciences
Volume31
Issue number1
DOIs
StatePublished - Jul 5 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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