Correlation of the bioactivity of luteinizing hormone in follicular fluid with oocyte maturity in the spontaneous cycle

K. Y. Cha, R. B. Barnes, R. P. Marrs, R. A. Lobo

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9 Scopus citations

Abstract

This study was done to measure the bioactivity of luteinizing hormone (LH) in follicular fluid (FF) and to correlate this and other hormonal values with oocyte maturity in the spontaneous cycle. Twenty follicles (> 18 mm) from 18 ovulatory patients were obtained, and FF, according to oocyte maturity, was divided into three groups (I to III) of increasing maturity. FF progesterone correlated with maturity and was highest (P < 0.01) in group III; estradiol, prolactin, and follicle-stimulating hormone were similar in the three groups. Immunoreactive LH was similar in groups I and II but was highest (30.5 ± 7 mIU/ml) in group III (P < 0.02). Bioactive (bio) LH was much higher in group III follicles (1307 ± 387 mIU/ml); the bio:immunoreactive LH ratio also increased significantly (P < 0.05). FF progesterone correlated positively with bio LH (r = 0.89, P < 0.005) and the bio:immunoreactive LH ratio (r = 0.9, P < 0.001); immunoreactive LH did not correlate. These data suggest that bioactivity of LH is an important correlate of oocyte maturity and that local ovarian factors may modulate these concentrations in FF.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalFertility and Sterility
Volume45
Issue number3
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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