Abstract
Objective. To investigate whether changes in peripheral blood lymphocytes correlate with changes in disease activity in juvenile dermatomyositis (JDM). Methods. Clinical changes in disease expression measured by a disease activity score were correlated with changes in percentages of peripheral blood lymphocyte subsets. Results. Changes in the percentage of peripheral blood CD 19 positive lymphocytes (B cells) correlated with changes in disease activity (Spearman rank coefficients = 0.47, p = 0.02). There were no significant correlations in disease activity with changes of T cell subsets or the T cell activation markers CD25 or DR. Conclusion. Change in the percentage of peripheral blood B cells correlates with change in disease activity in patients with JDM. This variable may he of use as an indicator of immunologic activity and response to therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1830-1832 |
| Number of pages | 3 |
| Journal | Journal of Rheumatology |
| Volume | 24 |
| Issue number | 9 |
| State | Published - Sep 1997 |
Keywords
- Disease activity
- Juvenile dermatomyositis
- Lymphocytes
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology