Correlations between change in disease activity and changes in peripheral blood lymphocyte subsets in patients with juvenile dermatomyositis

Daniel M. Eisenstein*, Maurice R G O'Gorman, Lauren M. Pachman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Objective. To investigate whether changes in peripheral blood lymphocytes correlate with changes in disease activity in juvenile dermatomyositis (JDM). Methods. Clinical changes in disease expression measured by a disease activity score were correlated with changes in percentages of peripheral blood lymphocyte subsets. Results. Changes in the percentage of peripheral blood CD 19 positive lymphocytes (B cells) correlated with changes in disease activity (Spearman rank coefficients = 0.47, p = 0.02). There were no significant correlations in disease activity with changes of T cell subsets or the T cell activation markers CD25 or DR. Conclusion. Change in the percentage of peripheral blood B cells correlates with change in disease activity in patients with JDM. This variable may he of use as an indicator of immunologic activity and response to therapy.

Original languageEnglish (US)
Pages (from-to)1830-1832
Number of pages3
JournalJournal of Rheumatology
Volume24
Issue number9
StatePublished - Sep 1997

Keywords

  • Disease activity
  • Juvenile dermatomyositis
  • Lymphocytes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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