Correlations of antibiotic use and carbapenem resistance in enterobacteriaceae

Milena McLaughlin, M. Renee Advincula, Michael Malczynski, Chao Qi, Maureen Bolon, Marc H. Scheetz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

138 Scopus citations


Epidemiological studies have shown a link between carbapenem use and resistance; however, the clinical relationship between antibiotic consumption and the epidemiology of carbapenem-intermediate or -resistant Enterobacteriaceae (CIRE) remains unclear. This study sought to analyze temporal antibiotic consumption trends for relationships with incident CIRE. In total, 310,892 days of therapy and 55 deduplicated CIRE were analyzed. When conservative corrections were applied for multiple comparisons, carbapenem class use and piperacillin-tazobactam use retained significant positive and negative relationships with the incidence of CIRE, respectively.

Original languageEnglish (US)
Pages (from-to)5131-5133
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number10
StatePublished - Oct 2013

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology


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