Correlations of antibiotic use and carbapenem resistance in enterobacteriaceae

Milena McLaughlin; M. Renee Advincula; Michael Malczynski; Chao Qi; Maureen Bolon; Marc H. Scheetz

doi:10.1128/AAC.00607-13

Correlations of antibiotic use and carbapenem resistance in enterobacteriaceae

Milena McLaughlin, M. Renee Advincula, Michael Malczynski, Chao Qi, Maureen Bolon, Marc H. Scheetz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

Epidemiological studies have shown a link between carbapenem use and resistance; however, the clinical relationship between antibiotic consumption and the epidemiology of carbapenem-intermediate or -resistant Enterobacteriaceae (CIRE) remains unclear. This study sought to analyze temporal antibiotic consumption trends for relationships with incident CIRE. In total, 310,892 days of therapy and 55 deduplicated CIRE were analyzed. When conservative corrections were applied for multiple comparisons, carbapenem class use and piperacillin-tazobactam use retained significant positive and negative relationships with the incidence of CIRE, respectively.

Original language	English (US)
Pages (from-to)	5131-5133
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	57
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00607-13
State	Published - Oct 2013

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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10.1128/AAC.00607-13

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title = "Correlations of antibiotic use and carbapenem resistance in enterobacteriaceae",

abstract = "Epidemiological studies have shown a link between carbapenem use and resistance; however, the clinical relationship between antibiotic consumption and the epidemiology of carbapenem-intermediate or -resistant Enterobacteriaceae (CIRE) remains unclear. This study sought to analyze temporal antibiotic consumption trends for relationships with incident CIRE. In total, 310,892 days of therapy and 55 deduplicated CIRE were analyzed. When conservative corrections were applied for multiple comparisons, carbapenem class use and piperacillin-tazobactam use retained significant positive and negative relationships with the incidence of CIRE, respectively.",

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AU - McLaughlin, Milena

AU - Advincula, M. Renee

AU - Malczynski, Michael

AU - Qi, Chao

AU - Bolon, Maureen

AU - Scheetz, Marc H.

PY - 2013/10

Y1 - 2013/10

N2 - Epidemiological studies have shown a link between carbapenem use and resistance; however, the clinical relationship between antibiotic consumption and the epidemiology of carbapenem-intermediate or -resistant Enterobacteriaceae (CIRE) remains unclear. This study sought to analyze temporal antibiotic consumption trends for relationships with incident CIRE. In total, 310,892 days of therapy and 55 deduplicated CIRE were analyzed. When conservative corrections were applied for multiple comparisons, carbapenem class use and piperacillin-tazobactam use retained significant positive and negative relationships with the incidence of CIRE, respectively.

AB - Epidemiological studies have shown a link between carbapenem use and resistance; however, the clinical relationship between antibiotic consumption and the epidemiology of carbapenem-intermediate or -resistant Enterobacteriaceae (CIRE) remains unclear. This study sought to analyze temporal antibiotic consumption trends for relationships with incident CIRE. In total, 310,892 days of therapy and 55 deduplicated CIRE were analyzed. When conservative corrections were applied for multiple comparisons, carbapenem class use and piperacillin-tazobactam use retained significant positive and negative relationships with the incidence of CIRE, respectively.

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Correlations of antibiotic use and carbapenem resistance in enterobacteriaceae

Abstract

ASJC Scopus subject areas

UN SDGs

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