Cortex phellodendri Extract Relaxes Airway Smooth Muscle

Qiu Ju Jiang, Weiwei Chen, Hong Dan, Li Tan, He Zhu, Guangzhong Yang, Jinhua Shen, Yong Bo Peng, Ping Zhao, Lu Xue, Meng Fei Yu, Liqun Ma, Xiao Tang Si, Zhuo Wang, Jiapei Dai, Gangjian Qin, Chunbin Zou, Qing Hua Liu*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Cortex phellodendri is used to reduce fever and remove dampness and toxin. Berberine is an active ingredient of C. phellodendri. Berberine from Argemone ochroleuca can relax airway smooth muscle (ASM); however, whether the nonberberine component of C. phellodendri has similar relaxant action was unclear. An n-butyl alcohol extract of C. phellodendri (NBAECP, nonberberine component) was prepared, which completely inhibits high K+- and acetylcholine- (ACH-) induced precontraction of airway smooth muscle in tracheal rings and lung slices from control and asthmatic mice, respectively. The contraction induced by high K+ was also blocked by nifedipine, a selective blocker of L-type Ca2+ channels. The ACH-induced contraction was partially inhibited by nifedipine and pyrazole 3, an inhibitor of TRPC3 and STIM/Orai channels. Taken together, our data demonstrate that NBAECP can relax ASM by inhibiting L-type Ca2+ channels and TRPC3 and/or STIM/Orai channels, suggesting that NBAECP could be developed to a new drug for relieving bronchospasm.

Original languageEnglish (US)
Article number8703239
JournalEvidence-based Complementary and Alternative Medicine
Volume2016
DOIs
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Complementary and alternative medicine

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    Jiang, Q. J., Chen, W., Dan, H., Tan, L., Zhu, H., Yang, G., Shen, J., Peng, Y. B., Zhao, P., Xue, L., Yu, M. F., Ma, L., Si, X. T., Wang, Z., Dai, J., Qin, G., Zou, C., & Liu, Q. H. (2016). Cortex phellodendri Extract Relaxes Airway Smooth Muscle. Evidence-based Complementary and Alternative Medicine, 2016, [8703239]. https://doi.org/10.1155/2016/8703239