Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons

E. J. Mufson; A. D. Kehr; B. H. Wainer; M. M. Mesulam

doi:10.1016/0006-8993(87)90470-7

Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons

E. J. Mufson^*, A. D. Kehr, B. H. Wainer, M. M. Mesulam

^*Corresponding author for this work

Neurology

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52 Scopus citations

Abstract

Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons.

Original language	English (US)
Pages (from-to)	385-388
Number of pages	4
Journal	Brain research
Volume	417
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(87)90470-7
State	Published - Aug 11 1987

Keywords

Cholinergic
Cortex
Immunohistochemistry
Nucleus basalis
Rat
Somatostatin

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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Mufson, E. J., Kehr, A. D., Wainer, B. H., & Mesulam, M. M. (1987). Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons. Brain research, 417(2), 385-388. https://doi.org/10.1016/0006-8993(87)90470-7

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title = "Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons",

abstract = "Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons.",

keywords = "Cholinergic, Cortex, Immunohistochemistry, Nucleus basalis, Rat, Somatostatin",

author = "Mufson, {E. J.} and Kehr, {A. D.} and Wainer, {B. H.} and Mesulam, {M. M.}",

note = "Funding Information: We wish to thank Leah Christie for expert secretarial assistance. Supported in part by an ADRDA Faculty Scholar Award (E.J.M.), an Alzheimer's Funding Information: Research Center NIA AG05134, a Javits Neuroscience Investigator Award, and by the Parkinson's Disease Foundation.",

year = "1987",

month = aug,

day = "11",

doi = "10.1016/0006-8993(87)90470-7",

language = "English (US)",

volume = "417",

pages = "385--388",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "2",

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Mufson, EJ, Kehr, AD, Wainer, BH & Mesulam, MM 1987, 'Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons', Brain research, vol. 417, no. 2, pp. 385-388. https://doi.org/10.1016/0006-8993(87)90470-7

Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons. / Mufson, E. J.; Kehr, A. D.; Wainer, B. H. et al.
In: Brain research, Vol. 417, No. 2, 11.08.1987, p. 385-388.

Research output: Contribution to journal › Article › peer-review

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T1 - Cortical effects of neurotoxic damage to the nucleus basalis in rats

T2 - persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons

AU - Mufson, E. J.

AU - Kehr, A. D.

AU - Wainer, B. H.

AU - Mesulam, M. M.

N1 - Funding Information: We wish to thank Leah Christie for expert secretarial assistance. Supported in part by an ADRDA Faculty Scholar Award (E.J.M.), an Alzheimer's Funding Information: Research Center NIA AG05134, a Javits Neuroscience Investigator Award, and by the Parkinson's Disease Foundation.

PY - 1987/8/11

Y1 - 1987/8/11

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AB - Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons.

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KW - Rat

KW - Somatostatin

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Mufson EJ, Kehr AD, Wainer BH, Mesulam MM. Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons. Brain research. 1987 Aug 11;417(2):385-388. doi: 10.1016/0006-8993(87)90470-7

Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons

Abstract

Keywords

ASJC Scopus subject areas

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