Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons

E. J. Mufson*, A. D. Kehr, B. H. Wainer, M. M. Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons.

Original languageEnglish (US)
Pages (from-to)385-388
Number of pages4
JournalBrain research
Volume417
Issue number2
DOIs
StatePublished - Aug 11 1987

Keywords

  • Cholinergic
  • Cortex
  • Immunohistochemistry
  • Nucleus basalis
  • Rat
  • Somatostatin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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