Cortical ensembles orchestrate social competition through hypothalamic outputs

Nancy Padilla-Coreano, Kanha Batra, Makenzie Patarino, Zexin Chen, Rachel R. Rock, Ruihan Zhang, Sébastien B. Hausmann, Javier C. Weddington, Reesha Patel, Yu E. Zhang, Hao Shu Fang, Srishti Mishra, Deryn O. LeDuke, Jasmin Revanna, Hao Li, Matilde Borio, Rachelle Pamintuan, Aneesh Bal, Laurel R. Keyes, Avraham LibsterRomy Wichmann, Fergil Mills, Felix H. Taschbach, Gillian A. Matthews, James P. Curley, Ila R. Fiete, Cewu Lu*, Kay M. Tye*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Most social species self-organize into dominance hierarchies1,2, which decreases aggression and conserves energy3,4, but it is not clear how individuals know their social rank. We have only begun to learn how the brain represents social rank5–9 and guides behaviour on the basis of this representation. The medial prefrontal cortex (mPFC) is involved in social dominance in rodents7,8 and humans10,11. Yet, precisely how the mPFC encodes relative social rank and which circuits mediate this computation is not known. We developed a social competition assay in which mice compete for rewards, as well as a computer vision tool (AlphaTracker) to track multiple, unmarked animals. A hidden Markov model combined with generalized linear models was able to decode social competition behaviour from mPFC ensemble activity. Population dynamics in the mPFC predicted social rank and competitive success. Finally, we demonstrate that mPFC cells that project to the lateral hypothalamus promote dominance behaviour during reward competition. Thus, we reveal a cortico-hypothalamic circuit by which the mPFC exerts top-down modulation of social dominance.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
Issue number7902
StatePublished - Mar 24 2022

ASJC Scopus subject areas

  • General


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