Cortical involvement in acquisition and extinction of trace eyeblink conditioning

A. P. Weible*, M. D. McEchron, J. F. Disterhoft

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

188 Scopus citations


Previous studies have implicated 2 cortical regions interconnected with the hippocampal formation, the retrosplenial cortex (RSC) and the medial prefrontal cortex (mPFC), as loci important for the acquisition of hippocampally dependent trace eyeblink conditioning. These loci have also been proposed to serve as long-term storage sites of task critical information. This study used lesions made prior to training to investigate the roles of the RSC, as well as the caudal and rostral subdivisions of the mPFC, in the acquisition and subsequent extinction of trace eyeblink conditioning in the rabbit. The caudal mPFC and rostral mPFC were shown to be critical for acquisition and extinction of the conditioned reflex, respectively. The data indicate that the RSC is not critical for acquisition or extinction of the trace conditioned reflex.

Original languageEnglish (US)
Pages (from-to)1058-1067
Number of pages10
JournalBehavioral Neuroscience
Issue number6
StatePublished - 2000

ASJC Scopus subject areas

  • Behavioral Neuroscience


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