Cortical overlap of joint representations contributes to the loss of independent joint control following stroke

Jun Yao*, Albert Chen, Carolina Carmona, Julius P A Dewald

*Corresponding author for this work

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The loss of independent joint control in the paretic upper limb is a cardinal sign of movement disorders following stroke. However, the underlying neural mechanisms for such a loss following stroke are still largely unknown. In order to investigate the possible contribution of altered sensorimotor cortical activity to the loss of independent joint control, we measured electroencephalographic (EEG) and torque signals during the generation of static shoulder/elbow torques. We found significant increases in the overlap of shoulder and elbow joint representations at the cortical level in stroke subjects as compared to control subjects. Linear regression results demonstrated significant associations between the cortical overlap of joint representations and the degree of the loss of independent joint control. Therefore, we conclude that an increased overlap of cortical representations for shoulder and elbow contributes to the expression of the loss of independent shoulder/elbow control of the paretic upper limb in chronic hemiparetic stroke survivors.

Original languageEnglish (US)
Pages (from-to)490-499
Number of pages10
JournalNeuroimage
Volume45
Issue number2
DOIs
StatePublished - Apr 1 2009

Fingerprint

Elbow
Joints
Stroke
Torque
Upper Extremity
Elbow Joint
Shoulder Joint
Movement Disorders
Linear Models

Keywords

  • Chronic hemiparetic stroke
  • Cortical motor maps
  • Electroencephalogram
  • Motor control
  • Muscle synergies

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

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abstract = "The loss of independent joint control in the paretic upper limb is a cardinal sign of movement disorders following stroke. However, the underlying neural mechanisms for such a loss following stroke are still largely unknown. In order to investigate the possible contribution of altered sensorimotor cortical activity to the loss of independent joint control, we measured electroencephalographic (EEG) and torque signals during the generation of static shoulder/elbow torques. We found significant increases in the overlap of shoulder and elbow joint representations at the cortical level in stroke subjects as compared to control subjects. Linear regression results demonstrated significant associations between the cortical overlap of joint representations and the degree of the loss of independent joint control. Therefore, we conclude that an increased overlap of cortical representations for shoulder and elbow contributes to the expression of the loss of independent shoulder/elbow control of the paretic upper limb in chronic hemiparetic stroke survivors.",
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Cortical overlap of joint representations contributes to the loss of independent joint control following stroke. / Yao, Jun; Chen, Albert; Carmona, Carolina; Dewald, Julius P A.

In: Neuroimage, Vol. 45, No. 2, 01.04.2009, p. 490-499.

Research output: Contribution to journalArticle

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AU - Chen, Albert

AU - Carmona, Carolina

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