Cortico-cortical networks in patients with ideomotor apraxia as revealed by EEG coherence analysis

Lewis A. Wheaton; Stephan Bohlhalter; Guido Nolte; Hiroshi Shibasaki; Noriaki Hattori; Esteban Fridman; Sherry Vorbach; Jordan Grafman; Mark Hallett

doi:10.1016/j.neulet.2007.12.065

Cortico-cortical networks in patients with ideomotor apraxia as revealed by EEG coherence analysis

Lewis A. Wheaton, Stephan Bohlhalter, Guido Nolte, Hiroshi Shibasaki, Noriaki Hattori, Esteban Fridman, Sherry Vorbach, Jordan Grafman, Mark Hallett^*

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We sought to determine whether coherent networks which circumvent lesioned cortex are seen in patients with ideomotor apraxia (IMA) while performing tool-use pantomimes. Five normal subjects and five patients with IMA (three patients with corticobasal degeneration and two with left hemisphere stroke) underwent 64-channel EEG recording while performing three tool-use pantomimes with their left hand in a self-paced manner. Beta band (20-22 Hz) coherence indicates that normal subjects have a dominant left hemisphere network responsible for praxis preparation, which was absent in patients. Corticobasal degeneration patients showed significant coherence increase between left parietal-right premotor areas. Left hemisphere stroke patients showed significant coherence increases in a right parietofrontal network. The right hemisphere appears to store useable praxis representations in IMA patients with left hemisphere damage.

Original language	English (US)
Pages (from-to)	87-92
Number of pages	6
Journal	Neuroscience Letters
Volume	433
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2007.12.065
State	Published - Mar 12 2008

Funding

This research was supported by Intramural Research Program, NINDS, NIH. Thanks to Drs. Edward Healton and Brendan Conroy, National Rehabilitation Hospital, Washington DC, for assistance with patient accrual. Special thanks to Devera Schoenberg, M.Sc., for editing.

Keywords

Coherence
Ideomotor apraxia
Parietal
Plasticity
Stroke

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2007.12.065

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title = "Cortico-cortical networks in patients with ideomotor apraxia as revealed by EEG coherence analysis",

abstract = "We sought to determine whether coherent networks which circumvent lesioned cortex are seen in patients with ideomotor apraxia (IMA) while performing tool-use pantomimes. Five normal subjects and five patients with IMA (three patients with corticobasal degeneration and two with left hemisphere stroke) underwent 64-channel EEG recording while performing three tool-use pantomimes with their left hand in a self-paced manner. Beta band (20-22 Hz) coherence indicates that normal subjects have a dominant left hemisphere network responsible for praxis preparation, which was absent in patients. Corticobasal degeneration patients showed significant coherence increase between left parietal-right premotor areas. Left hemisphere stroke patients showed significant coherence increases in a right parietofrontal network. The right hemisphere appears to store useable praxis representations in IMA patients with left hemisphere damage.",

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author = "Wheaton, {Lewis A.} and Stephan Bohlhalter and Guido Nolte and Hiroshi Shibasaki and Noriaki Hattori and Esteban Fridman and Sherry Vorbach and Jordan Grafman and Mark Hallett",

note = "Funding Information: This research was supported by Intramural Research Program, NINDS, NIH. Thanks to Drs. Edward Healton and Brendan Conroy, National Rehabilitation Hospital, Washington DC, for assistance with patient accrual. Special thanks to Devera Schoenberg, M.Sc., for editing.",

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AU - Shibasaki, Hiroshi

AU - Hattori, Noriaki

AU - Fridman, Esteban

AU - Vorbach, Sherry

AU - Grafman, Jordan

AU - Hallett, Mark

N1 - Funding Information: This research was supported by Intramural Research Program, NINDS, NIH. Thanks to Drs. Edward Healton and Brendan Conroy, National Rehabilitation Hospital, Washington DC, for assistance with patient accrual. Special thanks to Devera Schoenberg, M.Sc., for editing.

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N2 - We sought to determine whether coherent networks which circumvent lesioned cortex are seen in patients with ideomotor apraxia (IMA) while performing tool-use pantomimes. Five normal subjects and five patients with IMA (three patients with corticobasal degeneration and two with left hemisphere stroke) underwent 64-channel EEG recording while performing three tool-use pantomimes with their left hand in a self-paced manner. Beta band (20-22 Hz) coherence indicates that normal subjects have a dominant left hemisphere network responsible for praxis preparation, which was absent in patients. Corticobasal degeneration patients showed significant coherence increase between left parietal-right premotor areas. Left hemisphere stroke patients showed significant coherence increases in a right parietofrontal network. The right hemisphere appears to store useable praxis representations in IMA patients with left hemisphere damage.

AB - We sought to determine whether coherent networks which circumvent lesioned cortex are seen in patients with ideomotor apraxia (IMA) while performing tool-use pantomimes. Five normal subjects and five patients with IMA (three patients with corticobasal degeneration and two with left hemisphere stroke) underwent 64-channel EEG recording while performing three tool-use pantomimes with their left hand in a self-paced manner. Beta band (20-22 Hz) coherence indicates that normal subjects have a dominant left hemisphere network responsible for praxis preparation, which was absent in patients. Corticobasal degeneration patients showed significant coherence increase between left parietal-right premotor areas. Left hemisphere stroke patients showed significant coherence increases in a right parietofrontal network. The right hemisphere appears to store useable praxis representations in IMA patients with left hemisphere damage.

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Cortico-cortical networks in patients with ideomotor apraxia as revealed by EEG coherence analysis

Abstract

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