Corticosteroid Therapy in Epstein-Barr Virus Infection: Effect on Lymphocyte Class, Subset, and Response to Early Antigen

Alice Brandfonbrener, Alan Epstein, Samuel Wu, John Phair*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Corticosteroid treatment of impending upper airway obstruction due to Epstein-Barr virus (EBV) infectious mononucleosis did not alter the pattern of lymphocyte changes induced by this viral infection during the first two weeks following administration of prednisone. By 12 weeks, 11 treated students had significantly fewer lymphocytes, including B, total T, helper, and T-suppressor cell numbers, than 11 untreated EBV-infected students, and values were closer to those noted in uninfected controls. Corticosteroid therapy did not alter the serologic response to early antigens of EBV. Fever and lymphadenopathy resolved somewhat more quickly in treated students.

Original languageEnglish (US)
Pages (from-to)337-339
Number of pages3
JournalArchives of Internal Medicine
Volume146
Issue number2
DOIs
StatePublished - Feb 1986

ASJC Scopus subject areas

  • Internal Medicine

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