Corticostriatal connectivity and its role in disease

Gordon M.G. Shepherd*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

544 Scopus citations


Corticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons. Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all levels of functional organization, from cellular signalling mechanisms to circuit topology. There is also growing evidence for IT/PT imbalance as an aetiological factor in neurodevelopmental, neuropsychiatric and movement disorders-autism, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's and Parkinson's diseases and major depression are highlighted here.

Original languageEnglish (US)
Pages (from-to)278-291
Number of pages14
JournalNature Reviews Neuroscience
Issue number4
StatePublished - Apr 2013

ASJC Scopus subject areas

  • General Neuroscience


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