TY - JOUR
T1 - Corticostriatal connectivity and its role in disease
AU - Shepherd, Gordon M.G.
N1 - Funding Information:
I am grateful to M. D. Bevan, D. J. Surmeier and K. Svoboda for comments and suggestions, and to T. Kiritani for the image in figure 1.G.M.G.S. is supported by the US National Institutes of Health/National Institute of Neurological Disorders and Stroke grant NS061963.
PY - 2013/4
Y1 - 2013/4
N2 - Corticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons. Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all levels of functional organization, from cellular signalling mechanisms to circuit topology. There is also growing evidence for IT/PT imbalance as an aetiological factor in neurodevelopmental, neuropsychiatric and movement disorders-autism, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's and Parkinson's diseases and major depression are highlighted here.
AB - Corticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons. Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all levels of functional organization, from cellular signalling mechanisms to circuit topology. There is also growing evidence for IT/PT imbalance as an aetiological factor in neurodevelopmental, neuropsychiatric and movement disorders-autism, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's and Parkinson's diseases and major depression are highlighted here.
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U2 - 10.1038/nrn3469
DO - 10.1038/nrn3469
M3 - Review article
C2 - 23511908
AN - SCOPUS:84875478700
VL - 14
SP - 278
EP - 291
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
SN - 1471-003X
IS - 4
ER -