Corticostriatal functional connectivity predicts transition to chronic back pain

Marwan N. Baliki, Bogdan Petre, Souraya Torbey, Kristina M. Herrmann, Lejian Huang, Thomas J. Schnitzer, Howard L. Fields, A. Vania Apkarian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

531 Scopus citations

Abstract

The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.

Original languageEnglish (US)
Pages (from-to)1117-1119
Number of pages3
JournalNature neuroscience
Volume15
Issue number8
DOIs
StatePublished - Aug 2012

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Corticostriatal functional connectivity predicts transition to chronic back pain'. Together they form a unique fingerprint.

Cite this