Corticostriatal functional connectivity predicts transition to chronic back pain

Marwan N. Baliki; Bogdan Petre; Souraya Torbey; Kristina M. Herrmann; Lejian Huang; Thomas J. Schnitzer; Howard L. Fields; A. Vania Apkarian

doi:10.1038/nn.3153

Corticostriatal functional connectivity predicts transition to chronic back pain

Marwan N. Baliki, Bogdan Petre, Souraya Torbey, Kristina M. Herrmann, Lejian Huang, Thomas J. Schnitzer, Howard L. Fields, A. Vania Apkarian^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

835 Scopus citations

Abstract

The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.

Original language	English (US)
Pages (from-to)	1117-1119
Number of pages	3
Journal	Nature neuroscience
Volume	15
Issue number	8
DOIs	https://doi.org/10.1038/nn.3153
State	Published - Aug 2012

Funding

We thank all of the patients and healthy volunteers that participated in the study. The study was funded by the National Institute of Neurological Disorders and Stroke (NS35115). M.N.B. was funded by an anonymous foundation.

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1038/nn.3153

Cite this

@article{41f468869e9443449841cf6383c954e8,

title = "Corticostriatal functional connectivity predicts transition to chronic back pain",

abstract = "The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.",

author = "Baliki, {Marwan N.} and Bogdan Petre and Souraya Torbey and Herrmann, {Kristina M.} and Lejian Huang and Schnitzer, {Thomas J.} and Fields, {Howard L.} and Apkarian, {A. Vania}",

note = "Funding Information: We thank all of the patients and healthy volunteers that participated in the study. The study was funded by the National Institute of Neurological Disorders and Stroke (NS35115). M.N.B. was funded by an anonymous foundation.",

year = "2012",

month = aug,

doi = "10.1038/nn.3153",

language = "English (US)",

volume = "15",

pages = "1117--1119",

journal = "Nature neuroscience",

issn = "1097-6256",

publisher = "Nature Research",

number = "8",

}

TY - JOUR

T1 - Corticostriatal functional connectivity predicts transition to chronic back pain

AU - Baliki, Marwan N.

AU - Petre, Bogdan

AU - Torbey, Souraya

AU - Herrmann, Kristina M.

AU - Huang, Lejian

AU - Schnitzer, Thomas J.

AU - Fields, Howard L.

AU - Apkarian, A. Vania

N1 - Funding Information: We thank all of the patients and healthy volunteers that participated in the study. The study was funded by the National Institute of Neurological Disorders and Stroke (NS35115). M.N.B. was funded by an anonymous foundation.

PY - 2012/8

Y1 - 2012/8

N2 - The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.

AB - The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.

UR - http://www.scopus.com/inward/record.url?scp=84864451632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864451632&partnerID=8YFLogxK

U2 - 10.1038/nn.3153

DO - 10.1038/nn.3153

M3 - Article

C2 - 22751038

AN - SCOPUS:84864451632

SN - 1097-6256

VL - 15

SP - 1117

EP - 1119

JO - Nature neuroscience

JF - Nature neuroscience

IS - 8

ER -

Corticostriatal functional connectivity predicts transition to chronic back pain

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this