Corticotropin-releasing factor binding protein - A ligand trap?

Olaf Jahn, Jelena Radulovic, Oliver Stiedl, Hossein Tezval, Klaus Eckart, Joachim Spiess*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.

Original languageEnglish (US)
Pages (from-to)953-960
Number of pages8
JournalMini-Reviews in Medicinal Chemistry
Volume5
Issue number10
DOIs
StatePublished - Oct 1 2005

Keywords

  • CRF binding protein (CRFBP)
  • CRFBP inhibitor
  • Cognitive deficits
  • Corticotropin-releasing factor (CRF)
  • Urocortin

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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