TY - JOUR
T1 - Cost-effectiveness analysis of dose-dense versus standard intravenous chemotherapy for ovarian cancer
T2 - An economic analysis of results from the Gynecologic Oncology Group protocol 262 randomized controlled trial
AU - Seagle, Brandon Luke L.
AU - Shahabi, Shohreh
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Objectives To determine the cost-effectiveness of dose-dense versus standard intravenous adjuvant chemotherapy for ovarian cancer using results from the no-bevacizumab cohort of the Gynecologic Oncology Group protocol 262 (GOG-262) randomized controlled trial, which reported a smaller absolute progression-free survival (PFS) benefit than the prior Japanese trial. Methods A three-state Markov decision model from a healthcare system perspective with a 21 day cycle length and 28 month time-horizon was used to calculate incremental cost-effectiveness ratio (ICER) values per progression-free life-year saved (PFLYS) using results from GOG-262. Costs of chemotherapy, complications, and surveillance were from Medicare or institutional data. PFS, discontinuation, and complication rates were from GOG-262. Time-dependent transition probabilities and within-cycle corrections were used. One-way and probabilistic sensitivity analyses were performed. Results The model produces standard and dose-dense cohorts with 84.3% and 68.3% progression event proportions at 28 months, matching GOG-262 rates at the trial's median follow-up. With a median PFS of 10.3 months after standard chemotherapy and a hazard ratio for progression of 0.62 after dose-dense therapy, the ICER for dose-dense chemotherapy is $8074.25 (95% confidence interval: $7615.97–$10,207.16) per PFLYS. ICER estimates are sensitive only to the hazard ratio estimate but do not exceed $100,000 per PFLYS. 99.8% of ICER estimates met a more stringent willingness-to-pay of $50,000 per PFLYS. The willingness-to-pay value at which there is a 90% probability of dose-dense treatment being cost-effective is $12,000 per PFLYS. Conclusions Dose-dense adjuvant chemotherapy is robustly cost-effective for advanced ovarian cancer from a healthcare system perspective based on results from GOG-262.
AB - Objectives To determine the cost-effectiveness of dose-dense versus standard intravenous adjuvant chemotherapy for ovarian cancer using results from the no-bevacizumab cohort of the Gynecologic Oncology Group protocol 262 (GOG-262) randomized controlled trial, which reported a smaller absolute progression-free survival (PFS) benefit than the prior Japanese trial. Methods A three-state Markov decision model from a healthcare system perspective with a 21 day cycle length and 28 month time-horizon was used to calculate incremental cost-effectiveness ratio (ICER) values per progression-free life-year saved (PFLYS) using results from GOG-262. Costs of chemotherapy, complications, and surveillance were from Medicare or institutional data. PFS, discontinuation, and complication rates were from GOG-262. Time-dependent transition probabilities and within-cycle corrections were used. One-way and probabilistic sensitivity analyses were performed. Results The model produces standard and dose-dense cohorts with 84.3% and 68.3% progression event proportions at 28 months, matching GOG-262 rates at the trial's median follow-up. With a median PFS of 10.3 months after standard chemotherapy and a hazard ratio for progression of 0.62 after dose-dense therapy, the ICER for dose-dense chemotherapy is $8074.25 (95% confidence interval: $7615.97–$10,207.16) per PFLYS. ICER estimates are sensitive only to the hazard ratio estimate but do not exceed $100,000 per PFLYS. 99.8% of ICER estimates met a more stringent willingness-to-pay of $50,000 per PFLYS. The willingness-to-pay value at which there is a 90% probability of dose-dense treatment being cost-effective is $12,000 per PFLYS. Conclusions Dose-dense adjuvant chemotherapy is robustly cost-effective for advanced ovarian cancer from a healthcare system perspective based on results from GOG-262.
UR - http://www.scopus.com/inward/record.url?scp=85011999535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011999535&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2017.02.014
DO - 10.1016/j.ygyno.2017.02.014
M3 - Article
C2 - 28196674
AN - SCOPUS:85011999535
SN - 0090-8258
VL - 145
SP - 9
EP - 14
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 1
ER -
