TY - JOUR

T1 - Cost-effectiveness analysis of dose-dense versus standard intravenous chemotherapy for ovarian cancer

T2 - An economic analysis of results from the Gynecologic Oncology Group protocol 262 randomized controlled trial

AU - Seagle, Brandon Luke L.

AU - Shahabi, Shohreh

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objectives To determine the cost-effectiveness of dose-dense versus standard intravenous adjuvant chemotherapy for ovarian cancer using results from the no-bevacizumab cohort of the Gynecologic Oncology Group protocol 262 (GOG-262) randomized controlled trial, which reported a smaller absolute progression-free survival (PFS) benefit than the prior Japanese trial. Methods A three-state Markov decision model from a healthcare system perspective with a 21 day cycle length and 28 month time-horizon was used to calculate incremental cost-effectiveness ratio (ICER) values per progression-free life-year saved (PFLYS) using results from GOG-262. Costs of chemotherapy, complications, and surveillance were from Medicare or institutional data. PFS, discontinuation, and complication rates were from GOG-262. Time-dependent transition probabilities and within-cycle corrections were used. One-way and probabilistic sensitivity analyses were performed. Results The model produces standard and dose-dense cohorts with 84.3% and 68.3% progression event proportions at 28 months, matching GOG-262 rates at the trial's median follow-up. With a median PFS of 10.3 months after standard chemotherapy and a hazard ratio for progression of 0.62 after dose-dense therapy, the ICER for dose-dense chemotherapy is $8074.25 (95% confidence interval: $7615.97–$10,207.16) per PFLYS. ICER estimates are sensitive only to the hazard ratio estimate but do not exceed $100,000 per PFLYS. 99.8% of ICER estimates met a more stringent willingness-to-pay of $50,000 per PFLYS. The willingness-to-pay value at which there is a 90% probability of dose-dense treatment being cost-effective is $12,000 per PFLYS. Conclusions Dose-dense adjuvant chemotherapy is robustly cost-effective for advanced ovarian cancer from a healthcare system perspective based on results from GOG-262.

AB - Objectives To determine the cost-effectiveness of dose-dense versus standard intravenous adjuvant chemotherapy for ovarian cancer using results from the no-bevacizumab cohort of the Gynecologic Oncology Group protocol 262 (GOG-262) randomized controlled trial, which reported a smaller absolute progression-free survival (PFS) benefit than the prior Japanese trial. Methods A three-state Markov decision model from a healthcare system perspective with a 21 day cycle length and 28 month time-horizon was used to calculate incremental cost-effectiveness ratio (ICER) values per progression-free life-year saved (PFLYS) using results from GOG-262. Costs of chemotherapy, complications, and surveillance were from Medicare or institutional data. PFS, discontinuation, and complication rates were from GOG-262. Time-dependent transition probabilities and within-cycle corrections were used. One-way and probabilistic sensitivity analyses were performed. Results The model produces standard and dose-dense cohorts with 84.3% and 68.3% progression event proportions at 28 months, matching GOG-262 rates at the trial's median follow-up. With a median PFS of 10.3 months after standard chemotherapy and a hazard ratio for progression of 0.62 after dose-dense therapy, the ICER for dose-dense chemotherapy is $8074.25 (95% confidence interval: $7615.97–$10,207.16) per PFLYS. ICER estimates are sensitive only to the hazard ratio estimate but do not exceed $100,000 per PFLYS. 99.8% of ICER estimates met a more stringent willingness-to-pay of $50,000 per PFLYS. The willingness-to-pay value at which there is a 90% probability of dose-dense treatment being cost-effective is $12,000 per PFLYS. Conclusions Dose-dense adjuvant chemotherapy is robustly cost-effective for advanced ovarian cancer from a healthcare system perspective based on results from GOG-262.

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U2 - 10.1016/j.ygyno.2017.02.014

DO - 10.1016/j.ygyno.2017.02.014

M3 - Article

C2 - 28196674

AN - SCOPUS:85011999535

SN - 0090-8258

VL - 145

SP - 9

EP - 14

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 1

ER -