Costimulation couture: A designer approach to regulating autoimmunity

Mohammed Javeed Ansari, Mohamed H. Sayegh*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Negative or inhibitory costimulatory pathways regulate T cell activation and play a role in peripheral tolerance. Targeting these pathways harnesses the physiologic mechanisms of regulating autoimmunity and could prove beneficial for the therapy of autoimmune diseases. However, attempts at targeting these pathways have been fraught with difficulties. In this issue of the JCI, Fife et al. describe a creative approach for targeting CTL-associated antigen 4 (CTLA-4) on activated T cells via genetically engineered B cells to prevent autoimmune diabetes in the NOD mouse (see the related article beginning on page 2252). Novel "designer" strategies targeting negative costimulatory pathways provide reasons for optimism in the search for a cure for devastating autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)2080-2083
Number of pages4
JournalJournal of Clinical Investigation
Issue number8
StatePublished - Aug 1 2006

ASJC Scopus subject areas

  • General Medicine


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