TY - JOUR
T1 - Counterregulatory responses to insulin-induced glucose reduction in the elderly
AU - Meneilly, Graydon S.
AU - Minaker, Kenneth L.
AU - Young, James B.
AU - Landsberg, Lewis
AU - Rowe, John W.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1985/7
Y1 - 1985/7
N2 - The impact of age on counterregulatory responses to moderate reductions in blood glucose induced by aconstant insulin infusion (20 mU/m2-min) was studied in normal young (n = 7; aged 20-42 yr) and old (n = 7; aged 66-77 yr) nonobese subjects. Insulin was infused until the whole blood glucose level fell to or below 60 mg/dl. This required an infusion time of 39 ± 3 (±SE) min in the young and 36 ± 3 min in the old. Mean basal glucose [young, 88 ± 2 (±SE); old, 88 ± 2 mg/ dl), minimum glucose (young, 51 ± 2; old, 54 ± 1 mg/dl), time to nadir (young, 48 ± 3; old, 44 ±3), and time to recovery were similar in both groups. Maximal (young, 40.3 ± 2.3; old, 42.1 ± 3.3 /U/ml) insulin levels were also similar. Basal and maximal levels of glucagon, epinephrine, and GH were similar in the two groups. Although basal norepinephrine values were higher in the old subjects (young, 243 ± 38; old, 364 ± 23 pg/ml; P =0.02), increments above basal during reduction in blood glucose were not affected by age. Basal cortisol values were similar (young, 13.7 ± 1.4; old, 14.0 ± 0.7 g/dl), but maximum cortisol responses were slightly greater in the old subjects (young, 14.6 ± 1.0; old, 17.7 ± 0.9 eg/dl; P = 0.03). These studies indicate that hormonal responses and counterregulatory efficiency during modest reductions in blood glucose are preserved in healthy elderly subjects.
AB - The impact of age on counterregulatory responses to moderate reductions in blood glucose induced by aconstant insulin infusion (20 mU/m2-min) was studied in normal young (n = 7; aged 20-42 yr) and old (n = 7; aged 66-77 yr) nonobese subjects. Insulin was infused until the whole blood glucose level fell to or below 60 mg/dl. This required an infusion time of 39 ± 3 (±SE) min in the young and 36 ± 3 min in the old. Mean basal glucose [young, 88 ± 2 (±SE); old, 88 ± 2 mg/ dl), minimum glucose (young, 51 ± 2; old, 54 ± 1 mg/dl), time to nadir (young, 48 ± 3; old, 44 ±3), and time to recovery were similar in both groups. Maximal (young, 40.3 ± 2.3; old, 42.1 ± 3.3 /U/ml) insulin levels were also similar. Basal and maximal levels of glucagon, epinephrine, and GH were similar in the two groups. Although basal norepinephrine values were higher in the old subjects (young, 243 ± 38; old, 364 ± 23 pg/ml; P =0.02), increments above basal during reduction in blood glucose were not affected by age. Basal cortisol values were similar (young, 13.7 ± 1.4; old, 14.0 ± 0.7 g/dl), but maximum cortisol responses were slightly greater in the old subjects (young, 14.6 ± 1.0; old, 17.7 ± 0.9 eg/dl; P = 0.03). These studies indicate that hormonal responses and counterregulatory efficiency during modest reductions in blood glucose are preserved in healthy elderly subjects.
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U2 - 10.1210/jcem-61-1-178
DO - 10.1210/jcem-61-1-178
M3 - Article
C2 - 3889037
AN - SCOPUS:0021865560
VL - 61
SP - 178
EP - 182
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 1
ER -