Covalent modifications of histones during development and disease pathogenesis

Sukesh R. Bhaumik, Edwin Smith, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview article

456 Scopus citations

Abstract

Covalent modifications of histones are central to the regulation of chromatin dynamics, and, therefore, many biological processes involving chromatin, such as replication, repair, transcription and genome stability, are regulated by chromatin and its modifications. In this review, we discuss the biochemical, molecular and genetic properties of the enzymatic machinery involved in four different types of histone modification: acetylation, ubiquitination, phosphorylation and methylation. We also discuss how perturbation of the activity of this enzymatic machinery can cause developmental defects and disease.

Original languageEnglish (US)
Pages (from-to)1008-1016
Number of pages9
JournalNature Structural and Molecular Biology
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2007

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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