TY - JOUR
T1 - Covalent modifications of histones during development and disease pathogenesis
AU - Bhaumik, Sukesh R.
AU - Smith, Edwin
AU - Shilatifard, Ali
PY - 2007/11
Y1 - 2007/11
N2 - Covalent modifications of histones are central to the regulation of chromatin dynamics, and, therefore, many biological processes involving chromatin, such as replication, repair, transcription and genome stability, are regulated by chromatin and its modifications. In this review, we discuss the biochemical, molecular and genetic properties of the enzymatic machinery involved in four different types of histone modification: acetylation, ubiquitination, phosphorylation and methylation. We also discuss how perturbation of the activity of this enzymatic machinery can cause developmental defects and disease.
AB - Covalent modifications of histones are central to the regulation of chromatin dynamics, and, therefore, many biological processes involving chromatin, such as replication, repair, transcription and genome stability, are regulated by chromatin and its modifications. In this review, we discuss the biochemical, molecular and genetic properties of the enzymatic machinery involved in four different types of histone modification: acetylation, ubiquitination, phosphorylation and methylation. We also discuss how perturbation of the activity of this enzymatic machinery can cause developmental defects and disease.
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U2 - 10.1038/nsmb1337
DO - 10.1038/nsmb1337
M3 - Review article
C2 - 17984963
AN - SCOPUS:35848951163
SN - 1545-9993
VL - 14
SP - 1008
EP - 1016
JO - Nature Structural and Molecular Biology
JF - Nature Structural and Molecular Biology
IS - 11
ER -