COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men

Alexis R. Demonbreun; Amelia Sancilio; Matt E. Velez; Daniel T. Ryan; Lorenzo Pesce; Rana Saber; Lauren A. Vaught; Nina L. Reiser; Ryan R. Hsieh; Richard T. D'Aquila; Brian Mustanski; Thomas W. McDade; Elizabeth M. McNally

doi:10.1093/infdis/jiab314

COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men

Alexis R. Demonbreun^*, Amelia Sancilio, Matt E. Velez, Daniel T. Ryan, Lorenzo Pesce, Rana Saber, Lauren A. Vaught, Nina L. Reiser, Ryan R. Hsieh, Richard T. D'Aquila, Brian Mustanski, Thomas W. McDade, Elizabeth M. McNally

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 μg/mL, 51.6% vs 3.3 μg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 μg/mL) compared to men (20.6 μg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.

Original language	English (US)
Pages (from-to)	793-797
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	224
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jiab314
State	Published - Sep 1 2021

Keywords

COVID-19
ELISA
IgG
SARS-CoV-2
dried blood spots
neutralizing
receptor binding domain
serological testing
vaccine

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiab314

Cite this

Demonbreun, A. R., Sancilio, A., Velez, M. E., Ryan, D. T., Pesce, L., Saber, R., Vaught, L. A., Reiser, N. L., Hsieh, R. R., D'Aquila, R. T., Mustanski, B., McDade, T. W., & McNally, E. M. (2021). COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men. Journal of Infectious Diseases, 224(5), 793-797. https://doi.org/10.1093/infdis/jiab314

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abstract = "We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 μg/mL, 51.6% vs 3.3 μg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 μg/mL) compared to men (20.6 μg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.",

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note = "Funding Information: This work was supported by the National Science Foundation (grant number 2035114); National Institutes of Health (grant number 3UL1TR001422-06S4); Northwestern University Office of Research; and a generous gift from Dr Andrew Senyei and Noni Senyei. Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.",

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AU - McNally, Elizabeth M.

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COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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