Abstract
We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 μg/mL, 51.6% vs 3.3 μg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 μg/mL) compared to men (20.6 μg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.
Original language | English (US) |
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Pages (from-to) | 793-797 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 224 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1 2021 |
Keywords
- COVID-19
- ELISA
- IgG
- SARS-CoV-2
- dried blood spots
- neutralizing
- receptor binding domain
- serological testing
- vaccine
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases