COX1 and COX2 polymorphisms and gastric cancer risk in a polish population

Lifang Hou*, Paolo Grillo, Zhong Zheng Zhu, Jola Lissowska, Meredith Yeager, Witold Zatonski, Guanshan Zhu, Andrea Baccarelli, Stephen J. Chanock, Joseph F. Fraumeni, Wong Ho Chow

*Corresponding author for this work

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Background: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. Patients and Methods: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan™ assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. Results: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. Conclusion: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.

Original languageEnglish (US)
Pages (from-to)4243-4247
Number of pages5
JournalAnticancer research
Volume27
Issue number6 C
StatePublished - Nov 2007

Keywords

  • COX1
  • COX2
  • Gastric cancer
  • Polymorphisms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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