COX2 regulation of breast cancer bone metastasis

John Karavitis; Ming Zhang

doi:10.4161/onci.23129

COX2 regulation of breast cancer bone metastasis

John Karavitis, Ming Zhang^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

High expression levels of cyclooxygenase 2 expression and infiltration by regulatory T cells (Tregs) are often associated with tumor progression. We have recently reported a prostaglandin E₂ (PGE₂)-dependent recruitment of Tregs to the tumor, suggesting that targeting specific PGE₂ receptors may constitute a valuable approach to ablate the immunoediting that occurs along with disease progression.

Original language	English (US)
Article number	e23129
Journal	OncoImmunology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/onci.23129
State	Published - Mar 2013

Keywords

EP2
EP4
Immunosuppression
Immunotherapy
Mammary tumor
Regulatory T cell

ASJC Scopus subject areas

Oncology
Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4161/onci.23129

Cite this

@article{c4b6d681684c4f1e8b58c6d5c4ad75c2,

title = "COX2 regulation of breast cancer bone metastasis",

abstract = "High expression levels of cyclooxygenase 2 expression and infiltration by regulatory T cells (Tregs) are often associated with tumor progression. We have recently reported a prostaglandin E2 (PGE2)-dependent recruitment of Tregs to the tumor, suggesting that targeting specific PGE2 receptors may constitute a valuable approach to ablate the immunoediting that occurs along with disease progression.",

keywords = "EP2, EP4, Immunosuppression, Immunotherapy, Mammary tumor, Regulatory T cell",

author = "John Karavitis and Ming Zhang",

year = "2013",

month = mar,

doi = "10.4161/onci.23129",

language = "English (US)",

volume = "2",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Landes Bioscience",

number = "3",

}

TY - JOUR

T1 - COX2 regulation of breast cancer bone metastasis

AU - Karavitis, John

AU - Zhang, Ming

PY - 2013/3

Y1 - 2013/3

N2 - High expression levels of cyclooxygenase 2 expression and infiltration by regulatory T cells (Tregs) are often associated with tumor progression. We have recently reported a prostaglandin E2 (PGE2)-dependent recruitment of Tregs to the tumor, suggesting that targeting specific PGE2 receptors may constitute a valuable approach to ablate the immunoediting that occurs along with disease progression.

AB - High expression levels of cyclooxygenase 2 expression and infiltration by regulatory T cells (Tregs) are often associated with tumor progression. We have recently reported a prostaglandin E2 (PGE2)-dependent recruitment of Tregs to the tumor, suggesting that targeting specific PGE2 receptors may constitute a valuable approach to ablate the immunoediting that occurs along with disease progression.

KW - EP2

KW - EP4

KW - Immunosuppression

KW - Immunotherapy

KW - Mammary tumor

KW - Regulatory T cell

UR - http://www.scopus.com/inward/record.url?scp=84886944419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886944419&partnerID=8YFLogxK

U2 - 10.4161/onci.23129

DO - 10.4161/onci.23129

M3 - Article

C2 - 23802065

AN - SCOPUS:84886944419

SN - 2162-4011

VL - 2

JO - OncoImmunology

JF - OncoImmunology

IS - 3

M1 - e23129

ER -

COX2 regulation of breast cancer bone metastasis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this