COX2 regulation of breast cancer bone metastasis

John Karavitis, Ming Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

High expression levels of cyclooxygenase 2 expression and infiltration by regulatory T cells (Tregs) are often associated with tumor progression. We have recently reported a prostaglandin E2 (PGE2)-dependent recruitment of Tregs to the tumor, suggesting that targeting specific PGE2 receptors may constitute a valuable approach to ablate the immunoediting that occurs along with disease progression.

Original languageEnglish (US)
Article numbere23129
JournalOncoImmunology
Volume2
Issue number3
DOIs
StatePublished - Mar 1 2013

Keywords

  • EP2
  • EP4
  • Immunosuppression
  • Immunotherapy
  • Mammary tumor
  • Regulatory T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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