CRALBP transcriptional regulation in ciliary epithelial, retinal Müller and retinal pigment epithelial cells

Breandán N. Kennedy*, Chibo Li, Javier Ortego, Miguel Coca-Prados, Vijay P. Sarthy, John W. Crabb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Cellular retinaldehyde binding protein (CRALBP) functions in the visual cycle and mutations in the RLBP1 gene can lead to blindness. RLBP1 promoter analyses have been pursued in vitro as an approach to deciphering the mechanism controlling cell-specific expression of CRALBP. Reporter activity of wildtype and mutant RLBP1 promoter constructs suggest that CRALBP transcriptional regulation may be similar in the ciliary epithelium (CE) and retinal pigment epithelium (RPE) but different in Müller cells. Results in RPE cells refine the location of an RLBP1 enhancer element to within -1826 to -1749 bp and a repressor element to within -702 to -635 bp.

Original languageEnglish (US)
Pages (from-to)257-260
Number of pages4
JournalExperimental eye research
Volume76
Issue number2
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'CRALBP transcriptional regulation in ciliary epithelial, retinal Müller and retinal pigment epithelial cells'. Together they form a unique fingerprint.

Cite this