Cranial and spinal oligodendrogliomatosis: a case report and review of the literature

Siang Liao Lee, Albert Wong, James A. Stadler, Jamal McClendon, Timothy R. Smith, Nitin R. Wadhwani, Tadanori Tomita*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction: Oligodendrogliomatosis is a rarely reported entity in literature associated with poor prognosis in terms of length and quality of life. In this paper, we describe oligodendrogliomatosis in a 15-year-old male who initially presented with altered mental status due to diabetic ketoacidosis. Clinical presentation: He was refractory to temozolomide initially but demonstrated disease regression with radiotherapy (XRT). More recently, he has had disease recurrence, which was stabilized with temozolomide therapy for a period of time. Conclusion: Contrary to most reports in literature, our patient has had excellent quality of life since his initial diagnosis and continues to carry good prognosis. In addition to oligodendrogliomatosis, our patient also developed multiple intracranial cavernomas secondary to radiation therapy, which have remained stable and asymptomatic.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalChild's Nervous System
Volume31
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • 1p19q deletion
  • Chemotherapy
  • Lomustine
  • Oligodendrogliomatosis
  • Procarbazine
  • Radiation
  • Radiation-induced cavernomas
  • Temozolomide
  • Vincristine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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