Craniopharyngioma and Cushing disease. Case report

Adrian Caceres, Aaron J. Reitman, Tadanori Tomita*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Craniopharyngioma is a common sellar region tumor occurring in children. It usually manifests as endocrinological deficits such as short stature, delayed puberty, and obesity. Patients with craniopharyngioma commonly present with visual deficits and hydrocephalus. The authors present the case of a child who presented with short stature and clinical evidence of Cushing disease (CD) associated with a suprasellar tumor. The patient underwent insertion of an Ommaya reservoir into the tumor's cystic portion. High adrenocorticotropic hormone (ACTH) levels were demonstrated within the cyst's fluid and in the serum. After adequate decompression of the tumor, the patient underwent total resection. The tumor pathology was compatible with an adamantinomatous craniopharyngioma and immunohistochemical studies failed to show staining for ACTH. Panhypopituitarism developed postoperatively in the patient and he received hormone substitution therapy with final adequate height and normal-high weight. The neurosurgical implications of CD along with a possible mechanism for this patient's presentation are discussed in detail on the basis of the pertinent literature.

Original languageEnglish (US)
Pages (from-to)318-321
Number of pages4
JournalJournal of neurosurgery
Issue numberSUPPL. 3
StatePublished - Apr 2005


  • Brain neoplasm
  • Craniopharyngioma
  • Cushing disease
  • Obesity
  • Panhypopituitarism
  • Pediatric neurosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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