Creatine kinase and aldolase in serum: Abnormality common to acute psychoses

Herbert Meltzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Activity of creatine kinase and aldolase in serum increased in 14 of 16 patients with recent onset of a psychotic reaction, and in five of six patients treated with psychotomimetic drugs. There was either no increase of these enzymes or a slight increase in severely agitated (or depressed) non-psychotic hospitalized patients and chronic psychotic patients. The increase of the enzymes preceded the onset of the acute psychotic symptoms in at least three cases, was highest during the first 2 weeks of a psychotic episode, and sometimes recurred throughout the illness, particularly at times of stress. The creatine kinase in the serum is primarily of the muscle type.

Original languageEnglish (US)
Pages (from-to)1368-1370
Number of pages3
Issue number3821
StatePublished - 1968

ASJC Scopus subject areas

  • General


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