Creatine Phosphokinase Activity and Clinical Symptomatology: A Study in Acute Schizophrenic Patients

Herbert Y. Meltzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Serum creatine phosphokinase (CPK) and aldolase activities determined at admission and throughout hospitalization in 34 acute schizophrenic patients revealed 22 with increased activity of one or both enzymes. There was no difference in the percentage of paranoid and nonparanoid schizophrenic diagnoses in the patients with or without increased serum CPK or aldolase activities, nor were the magnitude of the increases in serum CPK or aldolase activities significantly different. The second-order factor scores of the Inpatient Multidimensional Psychiatric Scale also did not differentiate patients with elevated or normal serum enzyme activities. Results indicate the necessity of studying psychotic patients from the onset of gross psychotic symptoms with repeated study of both serum CPK and aldolase activities throughout hospitalization before subgroups of psychotic patients with and without increased serum CPK or aldolase activities may be reliably discriminated.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalArchives of general psychiatry
Volume29
Issue number5
DOIs
StatePublished - Nov 1973

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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