Abstract
A rapid rise in the cytosolic free Ca2+ concentration due to influx of extracellular Ca2+ or mobilization from intracellular stores is the primary trigger for exocytosis from secretory cells. Our understanding as to the precise role of Ca2+ mobilization has been complicated by the presence of several types of Ca2+ stores in most cells. We now demonstrate that overexpression of the type 3 inositol 1,4,5-trisphosphate (IP3) receptor in insulin-secreting βTC-3 cells results in the creation of a unique IP3- sensitive Ca2+ pool, restricted to the insulin secretory granules of these cells.
Original language | English (US) |
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Pages (from-to) | 27167-27170 |
Number of pages | 4 |
Journal | Journal of Biological Chemistry |
Volume | 269 |
Issue number | 44 |
State | Published - 1994 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology