Creation of an inositol 1,4,5-trisphosphate-sensitive Ca2+ store in secretory granules of insulin-producing cells

O. Blondel, G. I. Bell*, M. Moody, R. J. Miller, S. J. Gibbons

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


A rapid rise in the cytosolic free Ca2+ concentration due to influx of extracellular Ca2+ or mobilization from intracellular stores is the primary trigger for exocytosis from secretory cells. Our understanding as to the precise role of Ca2+ mobilization has been complicated by the presence of several types of Ca2+ stores in most cells. We now demonstrate that overexpression of the type 3 inositol 1,4,5-trisphosphate (IP3) receptor in insulin-secreting βTC-3 cells results in the creation of a unique IP3- sensitive Ca2+ pool, restricted to the insulin secretory granules of these cells.

Original languageEnglish (US)
Pages (from-to)27167-27170
Number of pages4
JournalJournal of Biological Chemistry
Issue number44
StatePublished - 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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