CRISP

Catheterization RISk score for pediatrics: A Report from the Congenital Cardiac Interventional Study Consortium (CCISC)

David G. Nykanen*, Thomas J. Forbes, Wei Du, Abhay A. Divekar, Jaxk H. Reeves, Donald J. Hagler, Thomas E. Fagan, Carlos Ac Pedra, Gregory A. Fleming, Danyal M. Khan, Alexander J. Javois, Daniel H. Gruenstein, Shakeel A. Qureshi, Phillip M. Moore, David F Wax

*Corresponding author for this work

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Objectives We sought to develop a scoring system that predicts the risk of serious adverse events (SAE's) for individual pediatric patients undergoing cardiac catheterization procedures. Background Systematic assessment of risk of SAE in pediatric catheterization can be challenging in view of a wide variation in procedure and patient complexity as well as rapidly evolving technology. Methods A 10 component scoring system was originally developed based on expert consensus and review of the existing literature. Data from an international multi-institutional catheterization registry (CCISC) between 2008 and 2013 were used to validate this scoring system. In addition we used multivariate methods to further refine the original risk score to improve its predictive power of SAE's. Results: Univariate analysis confirmed the strong correlation of each of the 10 components of the original risk score with SAE attributed to a pediatric cardiac catheterization (P < 0.001 for all variables). Multivariate analysis resulted in a modified risk score (CRISP) that corresponds to an increase in value of area under a receiver operating characteristic curve (AUC) from 0.715 to 0.741. Conclusion The CRISP score predicts risk of occurrence of an SAE for individual patients undergoing pediatric cardiac catheterization procedures.

Original languageEnglish (US)
Pages (from-to)302-309
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Volume87
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Catheterization
Pediatrics
Cardiac Catheterization
antineoplaston A10
ROC Curve
Area Under Curve
Registries
Multivariate Analysis
Technology

Keywords

  • COMP - complications
  • pediatric catheterization/intervention

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Nykanen, David G. ; Forbes, Thomas J. ; Du, Wei ; Divekar, Abhay A. ; Reeves, Jaxk H. ; Hagler, Donald J. ; Fagan, Thomas E. ; Pedra, Carlos Ac ; Fleming, Gregory A. ; Khan, Danyal M. ; Javois, Alexander J. ; Gruenstein, Daniel H. ; Qureshi, Shakeel A. ; Moore, Phillip M. ; Wax, David F. / CRISP : Catheterization RISk score for pediatrics: A Report from the Congenital Cardiac Interventional Study Consortium (CCISC). In: Catheterization and Cardiovascular Interventions. 2016 ; Vol. 87, No. 2. pp. 302-309.
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title = "CRISP: Catheterization RISk score for pediatrics: A Report from the Congenital Cardiac Interventional Study Consortium (CCISC)",
abstract = "Objectives We sought to develop a scoring system that predicts the risk of serious adverse events (SAE's) for individual pediatric patients undergoing cardiac catheterization procedures. Background Systematic assessment of risk of SAE in pediatric catheterization can be challenging in view of a wide variation in procedure and patient complexity as well as rapidly evolving technology. Methods A 10 component scoring system was originally developed based on expert consensus and review of the existing literature. Data from an international multi-institutional catheterization registry (CCISC) between 2008 and 2013 were used to validate this scoring system. In addition we used multivariate methods to further refine the original risk score to improve its predictive power of SAE's. Results: Univariate analysis confirmed the strong correlation of each of the 10 components of the original risk score with SAE attributed to a pediatric cardiac catheterization (P < 0.001 for all variables). Multivariate analysis resulted in a modified risk score (CRISP) that corresponds to an increase in value of area under a receiver operating characteristic curve (AUC) from 0.715 to 0.741. Conclusion The CRISP score predicts risk of occurrence of an SAE for individual patients undergoing pediatric cardiac catheterization procedures.",
keywords = "COMP - complications, pediatric catheterization/intervention",
author = "Nykanen, {David G.} and Forbes, {Thomas J.} and Wei Du and Divekar, {Abhay A.} and Reeves, {Jaxk H.} and Hagler, {Donald J.} and Fagan, {Thomas E.} and Pedra, {Carlos Ac} and Fleming, {Gregory A.} and Khan, {Danyal M.} and Javois, {Alexander J.} and Gruenstein, {Daniel H.} and Qureshi, {Shakeel A.} and Moore, {Phillip M.} and Wax, {David F}",
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Nykanen, DG, Forbes, TJ, Du, W, Divekar, AA, Reeves, JH, Hagler, DJ, Fagan, TE, Pedra, CA, Fleming, GA, Khan, DM, Javois, AJ, Gruenstein, DH, Qureshi, SA, Moore, PM & Wax, DF 2016, 'CRISP: Catheterization RISk score for pediatrics: A Report from the Congenital Cardiac Interventional Study Consortium (CCISC)', Catheterization and Cardiovascular Interventions, vol. 87, no. 2, pp. 302-309. https://doi.org/10.1002/ccd.26300

CRISP : Catheterization RISk score for pediatrics: A Report from the Congenital Cardiac Interventional Study Consortium (CCISC). / Nykanen, David G.; Forbes, Thomas J.; Du, Wei; Divekar, Abhay A.; Reeves, Jaxk H.; Hagler, Donald J.; Fagan, Thomas E.; Pedra, Carlos Ac; Fleming, Gregory A.; Khan, Danyal M.; Javois, Alexander J.; Gruenstein, Daniel H.; Qureshi, Shakeel A.; Moore, Phillip M.; Wax, David F.

In: Catheterization and Cardiovascular Interventions, Vol. 87, No. 2, 01.02.2016, p. 302-309.

Research output: Contribution to journalReview article

TY - JOUR

T1 - CRISP

T2 - Catheterization RISk score for pediatrics: A Report from the Congenital Cardiac Interventional Study Consortium (CCISC)

AU - Nykanen, David G.

AU - Forbes, Thomas J.

AU - Du, Wei

AU - Divekar, Abhay A.

AU - Reeves, Jaxk H.

AU - Hagler, Donald J.

AU - Fagan, Thomas E.

AU - Pedra, Carlos Ac

AU - Fleming, Gregory A.

AU - Khan, Danyal M.

AU - Javois, Alexander J.

AU - Gruenstein, Daniel H.

AU - Qureshi, Shakeel A.

AU - Moore, Phillip M.

AU - Wax, David F

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Objectives We sought to develop a scoring system that predicts the risk of serious adverse events (SAE's) for individual pediatric patients undergoing cardiac catheterization procedures. Background Systematic assessment of risk of SAE in pediatric catheterization can be challenging in view of a wide variation in procedure and patient complexity as well as rapidly evolving technology. Methods A 10 component scoring system was originally developed based on expert consensus and review of the existing literature. Data from an international multi-institutional catheterization registry (CCISC) between 2008 and 2013 were used to validate this scoring system. In addition we used multivariate methods to further refine the original risk score to improve its predictive power of SAE's. Results: Univariate analysis confirmed the strong correlation of each of the 10 components of the original risk score with SAE attributed to a pediatric cardiac catheterization (P < 0.001 for all variables). Multivariate analysis resulted in a modified risk score (CRISP) that corresponds to an increase in value of area under a receiver operating characteristic curve (AUC) from 0.715 to 0.741. Conclusion The CRISP score predicts risk of occurrence of an SAE for individual patients undergoing pediatric cardiac catheterization procedures.

AB - Objectives We sought to develop a scoring system that predicts the risk of serious adverse events (SAE's) for individual pediatric patients undergoing cardiac catheterization procedures. Background Systematic assessment of risk of SAE in pediatric catheterization can be challenging in view of a wide variation in procedure and patient complexity as well as rapidly evolving technology. Methods A 10 component scoring system was originally developed based on expert consensus and review of the existing literature. Data from an international multi-institutional catheterization registry (CCISC) between 2008 and 2013 were used to validate this scoring system. In addition we used multivariate methods to further refine the original risk score to improve its predictive power of SAE's. Results: Univariate analysis confirmed the strong correlation of each of the 10 components of the original risk score with SAE attributed to a pediatric cardiac catheterization (P < 0.001 for all variables). Multivariate analysis resulted in a modified risk score (CRISP) that corresponds to an increase in value of area under a receiver operating characteristic curve (AUC) from 0.715 to 0.741. Conclusion The CRISP score predicts risk of occurrence of an SAE for individual patients undergoing pediatric cardiac catheterization procedures.

KW - COMP - complications

KW - pediatric catheterization/intervention

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U2 - 10.1002/ccd.26300

DO - 10.1002/ccd.26300

M3 - Review article

VL - 87

SP - 302

EP - 309

JO - Catheterization and Cardiovascular Interventions

JF - Catheterization and Cardiovascular Interventions

SN - 1522-1946

IS - 2

ER -