@inbook{a74e2f416e994078bf62c27b4b22669b,
title = "Critical Closing Pressure by Diffuse Correlation Spectroscopy in a Neonatal Piglet Model",
abstract = "The critical closing pressure (CrCP) of the cerebral vasculature is the arterial blood pressure (ABP) at which cerebral blood flow (CBF) ceases. Because the ABP of preterm infants is low and close to the CrCP, there is often no CBF during diastole. Thus, estimation of CrCP may become clinically relevant in preterm neonates. Transcranial Doppler (TCD) ultrasound has been used to estimate CrCP in preterm infants. Diffuse correlation spectroscopy (DCS) is a continuous, noninvasive optical technique that measures microvascular CBF. Our objective was to compare and validate CrCP measured by DCS versus TCD ultrasound. Hemorrhagic shock was induced in 13 neonatal piglets, and CBF was measured continuously by both modalities. CrCP was calculated using a model of cerebrovascular impedance, and CrCP determined by the two modalities showed good correlation by linear regression, median r2 = 0.8 (interquartile range (IQR) 0.71–0.87), and Bland-Altman analysis showed a median bias of −3.5 (IQR −4.6 to −0.28). This is the first comparison of CrCP determined by DCS versus TCD ultrasound in a neonatal piglet model of hemorrhagic shock. The difference in CrCP between the two modalities may be due to differences in vasomotor tone within the microvasculature of the cerebral arterioles versus the macrovasculature of a major cerebral artery.",
keywords = "Cerebral blood flow, Critical closing pressure, Diffuse correlation spectroscopy, Prematurity, Transcranial Doppler ultrasound",
author = "Elizondo, {Leah I.} and Vu, {Eric L.} and Kibler, {Kathleen K.} and Rios, {Danielle R.} and Easley, {R. Blaine} and Dean Andropoulos and Sebastian Acosta and Craig Rusin and Kenneth Brady and Rhee, {Christopher J.}",
note = "Funding Information: Acknowledgments C.J.R. is supported by the National Institutes of Funding Information: C.J.R. is supported by the National Institutes of Health (1K23NS091382). D.R.R. is supported by the National Institutes of Health (1K23HLI130522). The technical assistance of Leticia McGuffey was greatly appreciated. Funding Information: Health (1K23NS091382). D.R.R. is supported by the National Institutes of Health (1K23HLI130522). The technical assistance of Leticia McGuffey was greatly appreciated. Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG.",
year = "2021",
doi = "10.1007/978-3-030-59436-7_55",
language = "English (US)",
series = "Acta Neurochirurgica, Supplementum",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "295--299",
booktitle = "Acta Neurochirurgica, Supplementum",
address = "Germany",
}