Critical roles for Rictor/Sin1 complexes in interferondependent gene transcription and generation of antiproliferative responses

Surinder Kaur; Barbara Kroczynska; Bhumika Sharma; Antonella Sassano; Ahmet Dirim Arslan; Beata Majchrzak-Kita; Brady L. Stein; Brandon McMahon; Jessica K. Altman; Bing Su; Raffaele A. Calogero; Eleanor N. Fish; Leonidas C. Platanias

doi:10.1074/jbc.M113.537852

Critical roles for Rictor/Sin1 complexes in interferondependent gene transcription and generation of antiproliferative responses

Surinder Kaur, Barbara Kroczynska, Bhumika Sharma, Antonella Sassano, Ahmet Dirim Arslan, Beata Majchrzak-Kita, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Bing Su, Raffaele A. Calogero, Eleanor N. Fish, Leonidas C. Platanias^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background: The precise roles for Rictor/Sin1 complexes in IFN signaling remain to be defined. Results: Targeted disruption Rictor/Sin1 results in defects in activation of elements of Stat pathways. These proteins are required for IFN antineoplastic effects on malignant erythroid precursors. Conclusion: Rictor/Sin1 play critical roles in IFN signaling. Significance: This study provides evidence for a key mechanism for gene regulation associated with generation of IFN antineoplastic responses.

Original language	English (US)
Pages (from-to)	6581-6591
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M113.537852
State	Published - Mar 7 2014

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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Kaur, S., Kroczynska, B., Sharma, B., Sassano, A., Arslan, A. D., Majchrzak-Kita, B., Stein, B. L., McMahon, B., Altman, J. K., Su, B., Calogero, R. A., Fish, E. N., & Platanias, L. C. (2014). Critical roles for Rictor/Sin1 complexes in interferondependent gene transcription and generation of antiproliferative responses. Journal of Biological Chemistry, 289(10), 6581-6591. https://doi.org/10.1074/jbc.M113.537852

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title = "Critical roles for Rictor/Sin1 complexes in interferondependent gene transcription and generation of antiproliferative responses",

abstract = "Background: The precise roles for Rictor/Sin1 complexes in IFN signaling remain to be defined. Results: Targeted disruption Rictor/Sin1 results in defects in activation of elements of Stat pathways. These proteins are required for IFN antineoplastic effects on malignant erythroid precursors. Conclusion: Rictor/Sin1 play critical roles in IFN signaling. Significance: This study provides evidence for a key mechanism for gene regulation associated with generation of IFN antineoplastic responses.",

author = "Surinder Kaur and Barbara Kroczynska and Bhumika Sharma and Antonella Sassano and Arslan, {Ahmet Dirim} and Beata Majchrzak-Kita and Stein, {Brady L.} and Brandon McMahon and Altman, {Jessica K.} and Bing Su and Calogero, {Raffaele A.} and Fish, {Eleanor N.} and Platanias, {Leonidas C.}",

year = "2014",

month = mar,

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doi = "10.1074/jbc.M113.537852",

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Kaur, S, Kroczynska, B, Sharma, B, Sassano, A, Arslan, AD, Majchrzak-Kita, B, Stein, BL, McMahon, B, Altman, JK, Su, B, Calogero, RA, Fish, EN & Platanias, LC 2014, 'Critical roles for Rictor/Sin1 complexes in interferondependent gene transcription and generation of antiproliferative responses', Journal of Biological Chemistry, vol. 289, no. 10, pp. 6581-6591. https://doi.org/10.1074/jbc.M113.537852

TY - JOUR

T1 - Critical roles for Rictor/Sin1 complexes in interferondependent gene transcription and generation of antiproliferative responses

AU - Kaur, Surinder

AU - Kroczynska, Barbara

AU - Sharma, Bhumika

AU - Sassano, Antonella

AU - Arslan, Ahmet Dirim

AU - Majchrzak-Kita, Beata

AU - Stein, Brady L.

AU - McMahon, Brandon

AU - Altman, Jessica K.

AU - Su, Bing

AU - Calogero, Raffaele A.

AU - Fish, Eleanor N.

AU - Platanias, Leonidas C.

PY - 2014/3/7

Y1 - 2014/3/7

N2 - Background: The precise roles for Rictor/Sin1 complexes in IFN signaling remain to be defined. Results: Targeted disruption Rictor/Sin1 results in defects in activation of elements of Stat pathways. These proteins are required for IFN antineoplastic effects on malignant erythroid precursors. Conclusion: Rictor/Sin1 play critical roles in IFN signaling. Significance: This study provides evidence for a key mechanism for gene regulation associated with generation of IFN antineoplastic responses.

AB - Background: The precise roles for Rictor/Sin1 complexes in IFN signaling remain to be defined. Results: Targeted disruption Rictor/Sin1 results in defects in activation of elements of Stat pathways. These proteins are required for IFN antineoplastic effects on malignant erythroid precursors. Conclusion: Rictor/Sin1 play critical roles in IFN signaling. Significance: This study provides evidence for a key mechanism for gene regulation associated with generation of IFN antineoplastic responses.

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 10

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Critical roles for Rictor/Sin1 complexes in interferondependent gene transcription and generation of antiproliferative responses

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