Critical roles for Rictor/Sin1 complexes in interferondependent gene transcription and generation of antiproliferative responses

Surinder Kaur, Barbara Kroczynska, Bhumika Sharma, Antonella Sassano, Ahmet Dirim Arslan, Beata Majchrzak-Kita, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Bing Su, Raffaele A. Calogero, Eleanor N. Fish, Leonidas C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Background: The precise roles for Rictor/Sin1 complexes in IFN signaling remain to be defined. Results: Targeted disruption Rictor/Sin1 results in defects in activation of elements of Stat pathways. These proteins are required for IFN antineoplastic effects on malignant erythroid precursors. Conclusion: Rictor/Sin1 play critical roles in IFN signaling. Significance: This study provides evidence for a key mechanism for gene regulation associated with generation of IFN antineoplastic responses.

Original languageEnglish (US)
Pages (from-to)6581-6591
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number10
DOIs
StatePublished - Mar 7 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Kaur, S., Kroczynska, B., Sharma, B., Sassano, A., Arslan, A. D., Majchrzak-Kita, B., Stein, B. L., McMahon, B., Altman, J. K., Su, B., Calogero, R. A., Fish, E. N., & Platanias, L. C. (2014). Critical roles for Rictor/Sin1 complexes in interferondependent gene transcription and generation of antiproliferative responses. Journal of Biological Chemistry, 289(10), 6581-6591. https://doi.org/10.1074/jbc.M113.537852