Crohn's disease therapy: Step up or top down therapy

S. B. Hanauer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


In most Crohn's disease scenarios a step-up approach has been used to initiate therapy according to disease severity. However, this approach has ignored the concept of inductive therapy followed by maintenance treatment to prevent relapse. It is apparent from clinical trials that the success of maintenance approaches will depend upon the inductive therapy. Furthermore, the step-up approach often results in steroid-dependent or refractory disease. The potential of aggressive initial therapy followed by step-down maintenance therapy affords the potential to modify the disease course, a possibility that has not been accomplished by current therapeutic algorithims.

Original languageEnglish (US)
Pages (from-to)189-190
Number of pages2
JournalActa Gastro-Enterologica Belgica
Issue number2
StatePublished - Jul 24 2001

ASJC Scopus subject areas

  • Gastroenterology


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