Cross-reactivity between peptide mimics of the immunodominant myelin proteolipid protein epitope PLP139-151: Comparison of peptide priming in CFA vs. viral delivery

Anne M. Ercolini, J. Ludovic Croxford, Mathew Degutes, Stephen D. Miller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Epidemiological evidence suggests that pathogens may trigger the development of autoimmune diseases such as multiple sclerosis (MS). Pathogens may trigger disease via molecular mimicry, wherein T cells generated against foreign epitopes are also cross-reactive with self-epitopes. Five pathogen-derived molecular mimics of PLP139-151 (the immunodominant CD4+ T cell myelin epitope in SJL mice) were previously identified. This study examines the degree of cross-reactivity between the different mimics, comparing mice primed with mimic peptide in CFA with mice infected with recombinant mimic-expressing viruses. The pattern of in vitro reactivity and ability to induce CNS disease differs between peptide priming and virus infection.

Original languageEnglish (US)
Pages (from-to)5-18
Number of pages14
JournalJournal of Neuroimmunology
Volume186
Issue number1-2
DOIs
StatePublished - May 2007

Keywords

  • Autoimmunity
  • EAE
  • Molecular mimicry
  • Multiple sclerosis
  • T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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