Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression

C. R. Chow*, K. Ebine, H. Z. Hattaway, K. Kumar, H. G. Munshi

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Patients with pancreatic cancer, which is characterized by a pronounced fibro-inflammatory reaction, often present with metastases. A critical step in cancer metastasis is epithelial-to-mesenchymal transition (EMT), which can be orchestrated by the Snail family of transcription factors. Significantly, mutations in K-ras are seen in <90% of human pancreatic ductal adenocarcinomas. In this chapter, we review the cross talk between Snail and mutant K-ras in regulating pancreatic cancer progression. We examine how the interplay between Snail and mutant K-ras mediates EMT, regulates fibrosis and inflammation in pancreatic tumors, and contributes to the generation of pancreatic cancer stem-like cells. We briefly also review the role of additional EMT-regulating transcription factors in pancreatic cancer progression.

Original languageEnglish (US)
Title of host publicationConquering RAS
Subtitle of host publicationFrom Biology to Cancer Therapy
PublisherElsevier Inc
Pages119-131
Number of pages13
ISBN (Electronic)9780128035412
ISBN (Print)9780128035054
DOIs
StatePublished - Jan 1 2017

Keywords

  • Cancer stem cells
  • EMT
  • Fibrosis
  • Inflammation
  • K-ras
  • Pancreatic cancer
  • Snail

ASJC Scopus subject areas

  • Medicine(all)

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