Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression

C. R. Chow*, K. Ebine, H. Z. Hattaway, K. Kumar, H. G. Munshi

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Patients with pancreatic cancer, which is characterized by a pronounced fibro-inflammatory reaction, often present with metastases. A critical step in cancer metastasis is epithelial-to-mesenchymal transition (EMT), which can be orchestrated by the Snail family of transcription factors. Significantly, mutations in K-ras are seen in <90% of human pancreatic ductal adenocarcinomas. In this chapter, we review the cross talk between Snail and mutant K-ras in regulating pancreatic cancer progression. We examine how the interplay between Snail and mutant K-ras mediates EMT, regulates fibrosis and inflammation in pancreatic tumors, and contributes to the generation of pancreatic cancer stem-like cells. We briefly also review the role of additional EMT-regulating transcription factors in pancreatic cancer progression.

Original languageEnglish (US)
Title of host publicationConquering RAS
Subtitle of host publicationFrom Biology to Cancer Therapy
PublisherElsevier Inc
Number of pages13
ISBN (Electronic)9780128035412
ISBN (Print)9780128035054
StatePublished - Jan 1 2017


  • Cancer stem cells
  • EMT
  • Fibrosis
  • Inflammation
  • K-ras
  • Pancreatic cancer
  • Snail

ASJC Scopus subject areas

  • Medicine(all)


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