Crosstalk between the DNA damage response, histone modifications and neovascularisation

Athanassios Vassilopoulos; Chu Xia Deng; Triantafyllos Chavakis

doi:10.1016/j.biocel.2009.11.020

Crosstalk between the DNA damage response, histone modifications and neovascularisation

Athanassios Vassilopoulos, Chu Xia Deng^*, Triantafyllos Chavakis

^*Corresponding author for this work

Radiation Oncology

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Neovascularisation is critical in several malignant and inflammatory conditions, as well as in the course of eye disorders. During new vessel formation, endothelial cell functions, such as proliferation and sprouting are very important and are regulated by a variety of growth factors. The DNA damage response machinery as well as factors regulating histone modifications, such as histone deacetylases, regulate cell fate as well as gene expression. Recent evidence has pointed to potential interactions among BRCA1, H2AX and SIRT1 in these intracellular pathways and neovascularisation, which will be reviewed here.

Original language	English (US)
Pages (from-to)	193-197
Number of pages	5
Journal	International Journal of Biochemistry and Cell Biology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/j.biocel.2009.11.020
State	Published - Feb 2010

Keywords

Angiogenesis
BRCA1
Sirtuins
γ-H2AX

ASJC Scopus subject areas

Biochemistry
Cell Biology

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10.1016/j.biocel.2009.11.020

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title = "Crosstalk between the DNA damage response, histone modifications and neovascularisation",

abstract = "Neovascularisation is critical in several malignant and inflammatory conditions, as well as in the course of eye disorders. During new vessel formation, endothelial cell functions, such as proliferation and sprouting are very important and are regulated by a variety of growth factors. The DNA damage response machinery as well as factors regulating histone modifications, such as histone deacetylases, regulate cell fate as well as gene expression. Recent evidence has pointed to potential interactions among BRCA1, H2AX and SIRT1 in these intracellular pathways and neovascularisation, which will be reviewed here.",

keywords = "Angiogenesis, BRCA1, Sirtuins, γ-H2AX",

author = "Athanassios Vassilopoulos and Deng, {Chu Xia} and Triantafyllos Chavakis",

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AU - Vassilopoulos, Athanassios

AU - Deng, Chu Xia

AU - Chavakis, Triantafyllos

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PY - 2010/2

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N2 - Neovascularisation is critical in several malignant and inflammatory conditions, as well as in the course of eye disorders. During new vessel formation, endothelial cell functions, such as proliferation and sprouting are very important and are regulated by a variety of growth factors. The DNA damage response machinery as well as factors regulating histone modifications, such as histone deacetylases, regulate cell fate as well as gene expression. Recent evidence has pointed to potential interactions among BRCA1, H2AX and SIRT1 in these intracellular pathways and neovascularisation, which will be reviewed here.

AB - Neovascularisation is critical in several malignant and inflammatory conditions, as well as in the course of eye disorders. During new vessel formation, endothelial cell functions, such as proliferation and sprouting are very important and are regulated by a variety of growth factors. The DNA damage response machinery as well as factors regulating histone modifications, such as histone deacetylases, regulate cell fate as well as gene expression. Recent evidence has pointed to potential interactions among BRCA1, H2AX and SIRT1 in these intracellular pathways and neovascularisation, which will be reviewed here.

KW - Angiogenesis

KW - BRCA1

KW - Sirtuins

KW - γ-H2AX

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ER -

Crosstalk between the DNA damage response, histone modifications and neovascularisation

Abstract

Keywords

ASJC Scopus subject areas

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