Crosstalk in glomerular injury and repair

Henrik Dimke, Yoshiro Maezawa, Susan E. Quaggin*

*Corresponding author for this work

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

Purpose of review The glomerulus is a unique structure required for filtration of blood, while retaining plasma proteins based on size and charge selectivity. Distinct cell types form the structural unit that creates the filtration barrier. Structurally, fenestrated endothelial cells line the capillary loops and lie in close contact with mesangial cells. Podocytes are connected by specialized intercellular junctions known as slit diaphragms and separated from the endothelial compartment by the glomerular basement membrane. In order for this highly specialized structure to function, cross-communication between these cells must occur. Recent findings Although classical studies have established key roles for vascular endothelial and platelet-derived growth factors in glomerular cross-communication, novel paracrine signaling pathways within the glomerulus have recently been identified. In addition, unique cellular pathways of established signaling cascades have been identified that are important for maintaining glomerular barrier function in health and disease. Summary Here, we will review our current understanding of the processes of cross-communication between the unique cellular constituents forming the glomerular filtration unit. We will highlight recent findings of cellular crosstalk via signaling pathways that regulate glomerular barrier function in pathophysiological conditions.

Original languageEnglish (US)
Pages (from-to)231-238
Number of pages8
JournalCurrent opinion in nephrology and hypertension
Volume24
Issue number3
DOIs
StatePublished - May 27 2015

Keywords

  • C-X-C chemokine ligand 12
  • activated protein C
  • angiopoietin
  • endothelin-1
  • vascular endothelial growth factor

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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