Abstract
(Chemical Equation Presented). Copper trafficking proteins, including the chaperone Atox1 and the P1B-type ATPase ATP7B, have been implicated in cellular resistance to the anticancer drug cisplatin. We have determined two crystal structures of cisplatin-Atox1 adducts that reveal platinum coordination by the conserved CXXC copper-binding motif. Direct interaction of cisplatin with this functionally relevant site has significant implications for understanding the molecular basis for resistance mediated by copper transport pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 14196-14197 |
| Number of pages | 2 |
| Journal | Journal of the American Chemical Society |
| Volume | 131 |
| Issue number | 40 |
| DOIs | |
| State | Published - Oct 14 2009 |
ASJC Scopus subject areas
- Catalysis
- General Chemistry
- Biochemistry
- Colloid and Surface Chemistry
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Dive into the research topics of 'Crystal structures of cisplatin bound to a human copper chaperone'. Together they form a unique fingerprint.Datasets
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Crystal structure of cisplatin bound to a human copper chaperone (dimer) - new refinement
Shabalin, I. (Contributor), Dauter, Z. (Contributor), Jaskolski, M. (Contributor), Minor, W. (Contributor), Wlodawer, A. (Contributor), Boal, A. K. (Contributor) & Rosenzweig, A. C. (Contributor), Protein Data Bank (PDB), Mar 18 2015
DOI: 10.2210/pdb4YEA/pdb, https://www.wwpdb.org/pdb?id=pdb_00004yea
Dataset
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Crystal structure of cisplatin bound to a human copper chaperone (monomer)
Boal, A. K. (Contributor) & Rosenzweig, A. C. (Contributor), Protein Data Bank (PDB), Sep 22 2009
DOI: 10.2210/pdb3IWL/pdb, https://www.wwpdb.org/pdb?id=pdb_00003iwl
Dataset
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Crystal structure of cisplatin bound to a human copper chaperone (dimer)
Boal, A. K. (Contributor) & Rosenzweig, A. C. (Contributor), Protein Data Bank (PDB), Sep 22 2009
DOI: 10.2210/pdb3IWX/pdb, https://www.wwpdb.org/pdb?id=pdb_00003iwx
Dataset