Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

Qing Huai, Aiwu Zhou, Lin Lin, Andrew P. Mazar, Graham C. Parry, Jennifer Callahan, David E. Shaw, Bruce Furie, Barbara C. Furie, Mingdong Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.

Original languageEnglish (US)
Pages (from-to)422-423
Number of pages2
JournalNature Structural and Molecular Biology
Volume15
Issue number4
DOIs
StatePublished - Apr 2008

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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