@article{5692dcda3a544636b71a488066409159,
title = "Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes",
abstract = "The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.",
author = "Qing Huai and Aiwu Zhou and Lin Lin and Mazar, {Andrew P.} and Parry, {Graham C.} and Jennifer Callahan and Shaw, {David E.} and Bruce Furie and Furie, {Barbara C.} and Mingdong Huang",
note = "Funding Information: This research is supported by grants from the US National Institutes of Health (HL08658) and the American Heart Association (0330089N) (to M.H.) and from the British Heart Foundation (to A.Z.). Data for this study were measured at beam lines ID19 and ID24 of Advanced Photon Sources and at beam line X29 of the the National Synchrotron Light Source.",
year = "2008",
month = apr,
doi = "10.1038/nsmb.1404",
language = "English (US)",
volume = "15",
pages = "422--423",
journal = "Nature Structural and Molecular Biology",
issn = "1545-9993",
publisher = "Nature Publishing Group",
number = "4",
}