Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

Qing Huai; Aiwu Zhou; Lin Lin; Andrew P. Mazar; Graham C. Parry; Jennifer Callahan; David E. Shaw; Bruce Furie; Barbara C. Furie; Mingdong Huang

doi:10.1038/nsmb.1404

Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

Qing Huai, Aiwu Zhou, Lin Lin, Andrew P. Mazar, Graham C. Parry, Jennifer Callahan, David E. Shaw, Bruce Furie, Barbara C. Furie, Mingdong Huang^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.

Original language	English (US)
Pages (from-to)	422-423
Number of pages	2
Journal	Nature Structural and Molecular Biology
Volume	15
Issue number	4
DOIs	https://doi.org/10.1038/nsmb.1404
State	Published - Apr 2008

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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title = "Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes",

abstract = "The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.",

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Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes. / Huai, Qing; Zhou, Aiwu; Lin, Lin; Mazar, Andrew P.; Parry, Graham C.; Callahan, Jennifer; Shaw, David E.; Furie, Bruce; Furie, Barbara C.; Huang, Mingdong.

In: Nature Structural and Molecular Biology, Vol. 15, No. 4, 04.2008, p. 422-423.

Research output: Contribution to journal › Article › peer-review

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