CSF antiretroviral drug penetrance and the treatment of HIV-associated psychomotor slowing

N. Sacktor*, P. M. Tarwater, R. L. Skolasky, J. C. McArthur, O. A. Selnes, J. Becker, B. Cohen, E. N. Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

The authors evaluated whether highly active antiretroviral therapy (HAART) with multiple CSF-penetrating drugs results in greater improvement in HIV-associated psychomotor slowing than HAART with a single CSF-penetrating drug. Both groups had improvement in CD4 count, plasma viral load, as well as two tests of psychomotor speed. Comparing the two groups, there were no differences in the mean change for CD4 count, viral load, or any of the neuropsychological tests. Multiple and single CSF-penetrating HAART may be equivalent for treating HIV-associated psychomotor slowing.

Original languageEnglish (US)
Pages (from-to)542-544
Number of pages3
JournalNeurology
Volume57
Issue number3
DOIs
StatePublished - Aug 14 2001

ASJC Scopus subject areas

  • Clinical Neurology

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