CSF phenylacetic acid and hostility in paranoid schizophrenia

Kym F. Faull; Roy J. King; Jack D. Barchas; John G. Csernansky

doi:10.1016/0165-1781(89)90152-2

CSF phenylacetic acid and hostility in paranoid schizophrenia

Kym F. Faull^*, Roy J. King, Jack D. Barchas, John G. Csernansky

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Lumbar cerebrospinal fluid concentrations of phenylacetic acid were significantly elevated in paranoid vs. nonparanoid schizophrenics. Further, phenylacetic acid concentrations were correlated with hostility. These results are consistent with the hypothesis that phenylethylamine, the proposed precursor of phenylacetic acid, plays a role in schizophrenia.

Original language	English (US)
Pages (from-to)	111-118
Number of pages	8
Journal	Psychiatry Research
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(89)90152-2
State	Published - Nov 1989

Funding

Acknowledgments. This work was supported by grants from the National Institute of Mental Health, MH-23861 (J.D.B.) and MH-30854 (J.G.C.), a grant from the Research Service of the Veterans Administration, and a grant from the John D. and Catherine T. MacArthur Foundation. We are grateful for the assistance of Dr. Philip Berger who was Director of the Clinical Research Center when most of the data reported herein were collected. The authors also thank Sarah Rawson and Allison Murchison for assistance in the collection of the data, Veronica Rudolph and Nina Pascoe for technical assistance, Sue Thiemann and Helena C. Kraemer, Ph.D., for statistical analysis, and Pamela J. Elliott for manuscript preparation and editorial advice.

Keywords

Cerebrospinal fluid
hostility
paranoid schizophrenia
phenylacetic acid

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-1781(89)90152-2

Cite this

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title = "CSF phenylacetic acid and hostility in paranoid schizophrenia",

abstract = "Lumbar cerebrospinal fluid concentrations of phenylacetic acid were significantly elevated in paranoid vs. nonparanoid schizophrenics. Further, phenylacetic acid concentrations were correlated with hostility. These results are consistent with the hypothesis that phenylethylamine, the proposed precursor of phenylacetic acid, plays a role in schizophrenia.",

keywords = "Cerebrospinal fluid, hostility, paranoid schizophrenia, phenylacetic acid",

author = "Faull, {Kym F.} and King, {Roy J.} and Barchas, {Jack D.} and Csernansky, {John G.}",

note = "Funding Information: Acknowledgments. This work was supported by grants from the National Institute of Mental Health, MH-23861 (J.D.B.) and MH-30854 (J.G.C.), a grant from the Research Service of the Veterans Administration, and a grant from the John D. and Catherine T. MacArthur Foundation. We are grateful for the assistance of Dr. Philip Berger who was Director of the Clinical Research Center when most of the data reported herein were collected. The authors also thank Sarah Rawson and Allison Murchison for assistance in the collection of the data, Veronica Rudolph and Nina Pascoe for technical assistance, Sue Thiemann and Helena C. Kraemer, Ph.D., for statistical analysis, and Pamela J. Elliott for manuscript preparation and editorial advice.",

year = "1989",

month = nov,

doi = "10.1016/0165-1781(89)90152-2",

language = "English (US)",

volume = "30",

pages = "111--118",

journal = "Psychiatry Research",

issn = "0165-1781",

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TY - JOUR

T1 - CSF phenylacetic acid and hostility in paranoid schizophrenia

AU - Faull, Kym F.

AU - King, Roy J.

AU - Barchas, Jack D.

AU - Csernansky, John G.

N1 - Funding Information: Acknowledgments. This work was supported by grants from the National Institute of Mental Health, MH-23861 (J.D.B.) and MH-30854 (J.G.C.), a grant from the Research Service of the Veterans Administration, and a grant from the John D. and Catherine T. MacArthur Foundation. We are grateful for the assistance of Dr. Philip Berger who was Director of the Clinical Research Center when most of the data reported herein were collected. The authors also thank Sarah Rawson and Allison Murchison for assistance in the collection of the data, Veronica Rudolph and Nina Pascoe for technical assistance, Sue Thiemann and Helena C. Kraemer, Ph.D., for statistical analysis, and Pamela J. Elliott for manuscript preparation and editorial advice.

PY - 1989/11

Y1 - 1989/11

N2 - Lumbar cerebrospinal fluid concentrations of phenylacetic acid were significantly elevated in paranoid vs. nonparanoid schizophrenics. Further, phenylacetic acid concentrations were correlated with hostility. These results are consistent with the hypothesis that phenylethylamine, the proposed precursor of phenylacetic acid, plays a role in schizophrenia.

AB - Lumbar cerebrospinal fluid concentrations of phenylacetic acid were significantly elevated in paranoid vs. nonparanoid schizophrenics. Further, phenylacetic acid concentrations were correlated with hostility. These results are consistent with the hypothesis that phenylethylamine, the proposed precursor of phenylacetic acid, plays a role in schizophrenia.

KW - Cerebrospinal fluid

KW - hostility

KW - paranoid schizophrenia

KW - phenylacetic acid

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JO - Psychiatry Research

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ER -

CSF phenylacetic acid and hostility in paranoid schizophrenia

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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