CSF ubiquitin as a specific biomarker in Alzheimer's disease

Ramesh J. Kandimalla, R. Anand*, R. Veeramanikandan, Willayat Yousuf Wani, Sudesh Prabhakar, Vinod K. Grover, Neerja Bharadwaj, Kajal Jain, Kiran Dip Gill

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Alzheimer's disease (AD) is the most common cause of dementia worldwide. Although, many putative biomarkers are reported for AD, only a few have been validated in the clinical setting. Ubiquitin levels increase in cerebrospinal fluid (CSF) of patients with AD, but its diagnostic value is not clear. In this present study we evaluate the performance of ubiquitin as a diagnostic marker and deduce a statistical association with disease pathology in AD. Ubiquitin levels were estimated in subjects with AD, other forms of dementias, neurological disorders and healthy age matched population. The levels of ubiquitin were significantly higher in subjects with AD when compared with other groups (p<0.0001). A significant positive correlation was observed between ubiquitin, tau and apolipoprotein Ee{open}4 genotype; with Aβ42 the correlation was negative. By comparing the effect size of the association between ubiquitin and a diagnosis of AD, we find that high ubiquitin levels are specific for AD. We obtained an odds ratio of 5.6 (95% CI 5.0-7.7) for ubiquitin, towards a diagnosis of AD based on clinical criteria, CSF biomarker signature (Aβ42+tau) and apolipoprotein Ee{open}4 genotype. Hence, all our findings taken together provide a strong statistical association linking ubiquitin to the pathology in AD. We also find that, the performance of ubiquitin as a diagnostic marker is comparable to that of CSF Aβ42 or tau or apolipoprotein Ee{open}4 genotype considered individually.

Original languageEnglish (US)
Pages (from-to)340-348
Number of pages9
JournalCurrent Alzheimer Research
Issue number4
StatePublished - 2014


  • Alzheimer's disease
  • Amyloid beta
  • Apolipoprotein Ee{open}4
  • Biomarkers
  • Cerebrospinal fluid
  • Ubiquitin

ASJC Scopus subject areas

  • Medicine(all)


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