Cullin 4-DCAF Proteins in Tumorigenesis

Zhuan Zhou, Xinxin Song, Cindy M. Wavelet, Yong Wan*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations


Cullin-RING ligase 4 (CRL4), a member of the cullin-RING ligase family, orchestrates a variety of critical cellular processes and pathophysiological events. Recent results from mouse genetics, clinical analyses, and biochemical studies have revealed the impact of CRL4 in development and cancer etiology and elucidated its in-depth mechanism on catalysis of ubiquitination as a ubiquitin E3 ligase. Here, we summarize the versatile roles of the CRL4 E3 ligase complexes in tumorigenesis dependent on the evidence obtained from knockout and transgenic mouse models as well as biochemical and pathological studies.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages19
StatePublished - Jan 1 2020

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Cancer etiology
  • CRL4 ligase and tumorigenesis
  • Cullin 4
  • DCAF
  • Mouse models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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