Cultured brain endothelium inhibits the cytocidal action of natural killer cells on glioma

Jack M. Rozentall*, Grazyna M. Kaminska, Marek J. Kaminski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The killing of GL26 and YAC-1 cells by natural killer cells (NKC) is reduced in the presence of a monolayer of endothelial cells. This reduction in cytotoxicity correlates with the degree of adhesion between the tumor cells and the endothelial monolayers. The cytotoxicity of NKC toward glioma was 10% when carried out on plastic, but a monolayer of endothelium derived from brain inhibited the cytotoxicity by about 90%. Endothelium from thoracic duct and lung also inhibited cytotoxicity by about 90%, endothelium from aorta inhibited by 55% and that from ovary by only 45%. Cytotoxicity of NKC toward YAC-1 (a control NK target) was 40% on plastic, but a monolayer of endothelium from thoracic duct inhibited the cytotoxicity by 75%. Endothelium from brain and lung inhibited cytotoxicity by about 60%, aorta by 50%, and ovary by 40%. Interactions between tumor cells and the host-organ microvascular endothelium appear to protect neoplastic cells from natural surveillance mechanisms and may play a role in the formation of metastatic tumor deposits.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalJournal of Neuro-Oncology
Volume7
Issue number1
DOIs
StatePublished - May 1 1989

Keywords

  • GL26
  • cytotoxicity
  • glioma
  • immunology
  • natural killer cells

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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