Cumulative tenofovir disoproxil fumarate exposure is associated with biomarkers of tubular injury and fibrosis in HIV-infected men

Vasantha Jotwani*, Rebecca Scherzer, Michelle M. Estrella, Lisa P. Jacobson, Mallory D. Witt, Frank Palella, Bernard MacAtangay, Michael Bennett, Chirag R. Parikh, Joachim H. Ix, Michael Shlipak

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Tenofovir disoproxil fumarate (TDF) can cause kidney damage, but current clinical tests are insensitive for detecting toxicity. Among 884 HIV-infected men enrolled in the Multicenter AIDS Cohort Study, we measured urine biomarkers specific for tubular damage (interleukin-18, kidney injury molecule-1, procollagen type III Nterminal propeptide) and albuminuria. In adjusted analyses, each year of TDF exposure was independently associated with 3.3% higher interleukin-18 (95% CI: 0.8% to 5.8%), 3.4% higher kidney injury molecule-1 (1.1% to 5.7%), and 3.1% higher procollagen type III Nterminal propeptide (0.8% to 5.5%), but not with albuminuria (2.8%; -0.6% to 6.2%). Biomarkers of tubular damage may be more sensitive than albuminuria for detecting toxicity from TDF and other medications.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume73
Issue number2
DOIs
StatePublished - Oct 1 2016

Keywords

  • Biomarker
  • Kidney
  • Nephrotoxicity
  • Tenofovir disoproxil fumarate

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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    Jotwani, V., Scherzer, R., Estrella, M. M., Jacobson, L. P., Witt, M. D., Palella, F., MacAtangay, B., Bennett, M., Parikh, C. R., Ix, J. H., & Shlipak, M. (2016). Cumulative tenofovir disoproxil fumarate exposure is associated with biomarkers of tubular injury and fibrosis in HIV-infected men. Journal of Acquired Immune Deficiency Syndromes, 73(2), 177-181. https://doi.org/10.1097/QAI.0000000000001027