Curcumin nanodisk-induced apoptosis in mantle cell lymphoma

Amareshwar T.K. Singh*, Mistuni Ghosh, Trudy M. Forte, Robert O. Ryan, Leo I. Gordon

*Corresponding author for this work

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Mantle cell lymphoma (MCL) is a pre-germinal center neoplasm characterized by cyclin D1 overexpression resulting from t(11;14)(q13;q32). Since MCL is incurable with standard lymphoma therapies, new treatment approaches are needed that target specific biologic pathways. In the present study, we investigated a novel drug delivery nanovehicle enriched with the bioactive polyphenol, curcumin (curcumin nanodisks; curcumin-ND). Cells treated with curcumin-ND showed a dose-dependent increase in apoptosis. This was accompanied by enhanced generation of reactive oxygen species (ROS). The antioxidant, N-acetylcysteine, inhibited curcumin-ND induced apoptosis, suggesting that ROS generation plays a role in curcumin action on MCL cells. Curcumin-ND decreased cyclin D1, pAkt, pIκB, and Bcl2 protein. In addition, enhanced FoxO3a and p27 expression as well as caspase-9, -3, and poly(ADP-ribose) polymerase (PARP) cleavage were observed. Curcumin-ND treatment led to enhanced G1 arrest in two cultured cell models of MCL.

Original languageEnglish (US)
Pages (from-to)1537-1543
Number of pages7
JournalLeukemia and Lymphoma
Volume52
Issue number8
DOIs
StatePublished - Aug 2011

Keywords

  • Nanodisks
  • apoptosis
  • cell cycle
  • curcumin
  • mantle cell lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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