Current applications of radiomics in the assessment of tumor microenvironment of hepatocellular carcinoma

Junghwa Choi; Andrew C Gordon; Aydin Eresen; Zhuoli Zhang; Amir Borhani; Ulas Bagci; Robert Lewandowski; Dong-Hyun Kim

doi:10.1007/s00261-025-04916-w

Current applications of radiomics in the assessment of tumor microenvironment of hepatocellular carcinoma

Junghwa Choi, Andrew C Gordon, Aydin Eresen, Zhuoli Zhang, Amir Borhani, Ulas Bagci, Robert Lewandowski, Dong-Hyun Kim^*

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Review article › peer-review

Abstract

The tumor microenvironment (TME) of hepatocellular carcinoma (HCC) has garnered significant attention, especially with the rise of immunotherapy as a treatment strategy. Radiomics, an innovative technique, offers valuable insights into the intricate structure of the TME. This review highlights recent advancements in radiomics for analyzing the HCC TME, identifies key areas that warrant further research, and explores comprehensive multi-omics approaches that extend the potential of radiomics to new frontiers.

Original language	English (US)
Journal	Abdominal Radiology
DOIs	https://doi.org/10.1007/s00261-025-04916-w
State	Accepted/In press - 2025

Keywords

Cancer therapy
Hepatocellular carcinoma
Immunotherapy
Radiomics
Tumor microenvironment

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Gastroenterology
Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00261-025-04916-w

Cite this

@article{eef4b73c61af4dfda88fcb654d2199e9,

title = "Current applications of radiomics in the assessment of tumor microenvironment of hepatocellular carcinoma",

abstract = "The tumor microenvironment (TME) of hepatocellular carcinoma (HCC) has garnered significant attention, especially with the rise of immunotherapy as a treatment strategy. Radiomics, an innovative technique, offers valuable insights into the intricate structure of the TME. This review highlights recent advancements in radiomics for analyzing the HCC TME, identifies key areas that warrant further research, and explores comprehensive multi-omics approaches that extend the potential of radiomics to new frontiers.",

keywords = "Cancer therapy, Hepatocellular carcinoma, Immunotherapy, Radiomics, Tumor microenvironment",

author = "Junghwa Choi and Gordon, \{Andrew C\} and Aydin Eresen and Zhuoli Zhang and Amir Borhani and Ulas Bagci and Robert Lewandowski and Dong-Hyun Kim",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.",

year = "2025",

doi = "10.1007/s00261-025-04916-w",

language = "English (US)",

journal = "Abdominal Radiology",

issn = "2366-004X",

publisher = "Springer",

}

TY - JOUR

T1 - Current applications of radiomics in the assessment of tumor microenvironment of hepatocellular carcinoma

AU - Choi, Junghwa

AU - Gordon, Andrew C

AU - Eresen, Aydin

AU - Zhang, Zhuoli

AU - Borhani, Amir

AU - Bagci, Ulas

AU - Lewandowski, Robert

AU - Kim, Dong-Hyun

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.

PY - 2025

Y1 - 2025

N2 - The tumor microenvironment (TME) of hepatocellular carcinoma (HCC) has garnered significant attention, especially with the rise of immunotherapy as a treatment strategy. Radiomics, an innovative technique, offers valuable insights into the intricate structure of the TME. This review highlights recent advancements in radiomics for analyzing the HCC TME, identifies key areas that warrant further research, and explores comprehensive multi-omics approaches that extend the potential of radiomics to new frontiers.

AB - The tumor microenvironment (TME) of hepatocellular carcinoma (HCC) has garnered significant attention, especially with the rise of immunotherapy as a treatment strategy. Radiomics, an innovative technique, offers valuable insights into the intricate structure of the TME. This review highlights recent advancements in radiomics for analyzing the HCC TME, identifies key areas that warrant further research, and explores comprehensive multi-omics approaches that extend the potential of radiomics to new frontiers.

KW - Cancer therapy

KW - Hepatocellular carcinoma

KW - Immunotherapy

KW - Radiomics

KW - Tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=105002256967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=105002256967&partnerID=8YFLogxK

U2 - 10.1007/s00261-025-04916-w

DO - 10.1007/s00261-025-04916-w

M3 - Review article

C2 - 40208284

AN - SCOPUS:105002256967

SN - 2366-004X

JO - Abdominal Radiology

JF - Abdominal Radiology

ER -

Current applications of radiomics in the assessment of tumor microenvironment of hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this