Current Concepts of Warfarin Therapy

Carol E. Peterson, Hau C. Kwaan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Oral anticoagulants are used extensively, although their risks are not always fully recognized. The prophylaxis of venous thrombosis after hip surgery, the prevention of deep venous thrombosis and pulmonary emboli after an acute episode of these, the prevention of arterial emboli from the heart in patients at risk, and the prophylaxis of thrombosis in patients with congenital deficiency of antithrombin III, protein C, or protein S are some of the indications for oral anticoagulant use. Warfarin sodium is contraindicated in pregnancy, however. The recommended prothrombin time is 1½ to two times control, lower than previously. The major risk of oral anticoagulant therapy, bleeding, is treated with vitamin K or plasma, depending on its severity. Warfarin necrosis and the “purple-toe” syndrome are seen more frequently than realized.

Original languageEnglish (US)
Pages (from-to)581-584
Number of pages4
JournalArchives of Internal Medicine
Issue number3
StatePublished - Mar 1986

ASJC Scopus subject areas

  • Internal Medicine


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